Long Noncoding RNA and Cancer: A New Paradigm.
Long Noncoding RNA and Cancer: A New Paradigm.
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DOI：
10.1158/0008-5472.can-16-2634
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发表时间：
2017-08-01
期刊：
影响因子：
11.2
通讯作者：
Mandal SS
中科院分区：
文献类型：
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作者：
Bhan A;Soleimani M;Mandal SS
除了蛋白质编码基因的突变或异常表达外，非编码rna的突变和错误调控，特别是长链非编码rna (lncRNA)，似乎在癌症中起着重要作用。肿瘤样本的全基因组关联研究（GWAS）已经发现了大量与各种类型癌症相关的lncrna。lncRNA表达的改变及其突变促进肿瘤的发生和转移。lncrna可能表现出抑制和促进肿瘤（致癌）的功能。由于其在多种组织中的全基因组表达模式及其组织特异性表达特征，lncrna作为新的生物标志物和癌症治疗靶点具有很强的前景。在这篇文章中，我们回顾了lncrna在不同类型癌症中的新功能和关联，并讨论了它们在癌症诊断和治疗中的潜在意义。
In addition to mutations or aberrant expression in the protein coding genes, mutations and misregulation of non-coding RNAs, in particular long noncoding RNAs (lncRNA), appear to play major roles in cancer. Genome-wide association studies (GWAS) of tumor samples have identified a large number of lncRNAs associated with various types of cancer. Alterations in lncRNA expression and their mutations promote tumorigenesis and metastasis. LncRNAs may exhibit tumor suppressive and promoting (oncogenic) functions. Due to their genome-wide expression patterns in a variety of tissues and their tissue-specific expression characteristics, lncRNAs hold strong promise as novel biomarkers and therapeutic targets for cancer. In this article, we have reviewed the emerging functions and association of lncRNAs in different types of cancer and discussed their potential implications in cancer diagnosis and therapy.