ATRIAL-NATRIURETIC-PEPTIDE AND PLASMA-VOLUME OF DOGS SUFFERING FROM HEART OR DEHYDRATION
ATRIAL-NATRIURETIC-PEPTIDE AND PLASMA-VOLUME OF DOGS SUFFERING FROM HEART OR DEHYDRATION
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DOI：
10.1111/j.1439-0442.1994.tb00122.x
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发表时间：
1994-09-01
期刊：
影响因子：
--
通讯作者：
SCHULTZ, R
中科院分区：
文献类型：
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作者：
VOLLMAR, AM;MONTAG, C;SCHULTZ, R
对人类和实验动物模型的研究表明，容量超负荷增加和容量欠负荷减少心房利钠肽（ANP）的释放，这是一种与水和电解质稳态密切相关的激素。在患有心力衰竭或脱水的犬中检查了这种关系，此处提供的数据支持这一一般概念。充血性心力衰竭（CHF）犬的血浆ANP浓度随疾病严重程度升高（NYHA分级，II级：21.4 +/- 9.2 fmol ANP/ml; III级：65.5 +/- 72.6; IV级：119.7 +/- 87.1;健康犬：13.9 +/- 7.5）。心脏病患者血浆ANP浓度的升高也与血浆容量呈正相关。中、重度CHF犬血容量显著增加（P < 0.05），血压正常。与此相反，脱水的狗倾向于显示降低的ANP血浆浓度（7.7 +/- 5.6 fmol/ml）以及显著降低的血浆容量和降低的血压（P < 0.05）。在患有严重CHF的狗中，ANP前体物质存在于血液中，通常无法检测到。这些数据进一步支持的概念，心钠素的调节功能的体积内稳态的狗。
Studies in humans and experimental animal models suggest that volume overload increases and volume underload decreases release of atrial natriuretic peptide (ANP), a hormone intimately linked to water and electrolyte homeostasis. This relationship was examined in dogs suffering from heart failure or dehydration and the data presented here are in support of this general concept. Plasma ANP concentration in dogs with congestive heart failure (CHF) was elevated with the severity of the disease (NYHA classification, class II: 21.4 +/- 9.2 fmol ANP/ml; class III: 65.5 +/- 72.6; class IV: 119.7 +/- 87.1; healthy dogs: 13.9 +/- 7.5). The increment in plasma ANP concentration in cardiac patients was also positively correlated with the plasma volume. The blood volume of dogs with moderate and severe CHF was significantly (P < 0.05) elevated and a normotonic blood pressure prevailed. In contrast, dehydrated dogs tend to display reduced ANP plasma concentration (7.7 +/- 5.6 fmol/ml) as well as significantly lower plasma volume and reduced blood pressure (P < 0.05). In dogs with severe CHF, ANP precursor material is present in the blood, which is normally undetectable. These data further support the concept of a regulatory function of ANP in volume homeostasis of dogs.