Studying cellular processes and detecting disease with protein microarrays.

Studying cellular processes and detecting disease with protein microarrays.
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使用蛋白质微阵列研究细胞过程并检测疾病。

DOI:
10.1080/03602530500205309
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发表时间:
2005
期刊:
Drug metabolism reviews.
影响因子:
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通讯作者:
Bollinger,Nikki
Bollinger,Nikki
中科院分区:
--
文献类型:
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作者:
Zangar,RichardC;Varnum,SusanM;Bollinger,Nikki

文献摘要

相似文献

蛋白质微阵列是一种快速发展的分析工具,在生物医学研究中有着广泛的应用。这些应用包括疾病标志物或自身免疫反应的分析,了解分子途径,蛋白质修饰和蛋白质活性。推动这种扩大使用的一个因素是蛋白质微阵列可以采用的各种各样的实验形式。在这篇综述中,我们提供了一个简短的,概念性的概述不同的方法蛋白质微阵列。然后,我们研究了这些微阵列的一些最重要的应用,重点是如何全球蛋白质分析可以用来促进生物医学研究。
Protein microarrays are a rapidly developing analytic tool with diverse applications in biomedical research. These applications include profiling of disease markers or autoimmune responses, understanding molecular pathways, protein modifications, and protein activities. One factor that is driving this expanding usage is the wide variety of experimental formats that protein microarrays can take. In this review, we provide a short, conceptual overview of the different approaches for protein microarray. We then examine some of the most significant applications of these microarrays to date, with an emphasis on how global protein analyses can be used to facilitate biomedical research.