Does sulfation of gastrin influence gastric acid secretion in man?
Does sulfation of gastrin influence gastric acid secretion in man?
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胃泌素硫酸化会影响人的胃酸分泌吗？
DOI：
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发表时间：
1990
影响因子：
1.9
通讯作者：
J. Rehfeld
中科院分区：
文献类型：
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作者：
P. Cantor;M. B. Petersen;John R. Christiansen;J. Rehfeld
为了评估人胃泌素酪氨酸邻硫酸化的生理意义，在6名正常年轻受试者中比较了硫酸化和非硫酸化人胃泌素-17的胃酸刺激效力。以12.7 - 478 pmol/kg/h的剂量静脉输注硫酸化和非硫酸化形式的合成人胃泌素-17。观察到类似的酸分泌反应。计算的硫酸化胃泌素-17的最大酸反应为35.7 +/- 4.3 mmol/h，非硫酸化胃泌素-17的最大酸反应为39.8 +/- 7.5 mmol/h（平均值+/- SEM，NS）。硫酸化胃泌素-17的50%有效剂量为22.2 +/- 6.7 pmol/kg/h，而非硫酸化胃泌素-17（NS）的50%有效剂量为29.3 +/- 5.8 pmol/kg/h。最后，血清中胃泌素的50%有效浓度为34.7 +/- 5.0 pmol硫酸化胃泌素-17/1和42.5 +/- 11.8 pmol非硫酸化胃泌素-17/1（NS）。结果表明，酪氨酸邻硫酸化对人胃泌素的胃酸分泌能力无明显影响，同时也提示人的硫酸化和非硫酸化胃泌素-17代谢速率相似。
To assess the physiologic significance of tyrosine o-sulfation of gastrin in humans, the gastric acid stimulatory potencies of sulfated and non-sulfated human gastrin-17 were compared in six normal young subjects. Sulfated and non-sulfated forms of synthetic human gastrin-17 were infused intravenously in doses from 12.7 to 478 pmol/kg/h. Similar acid secretory responses were observed. The calculated maximal acid response for sulfated gastrin-17 was 35.7 +/- 4.3 mmol/h, and that for non-sulfated gastrin-17 was 39.8 +/- 7.5 mmol/h (mean +/- SEM, NS). The 50% effective dose of sulfated gastrin-17 was 22.2 +/- 6.7 pmol/kg/h, whereas it was 29.3 +/- 5.8 pmol/kg/h for non-sulfated gastrin-17 (NS). Finally, the 50% effective concentration of gastrin in serum was 34.7 +/- 5.0 pmol sulfated gastrin-17/l and 42.5 +/- 11.8 pmol non-sulfated gastrin-17/l (NS). The results show that tyrosine o-sulfation is without significant influence on the gastric acid secretory potency of gastrin in man. Moreover, the results also suggest that sulfated and non-sulfated gastrin-17 in man have similar rates of metabolism.