GIANT CELL ASTROCYTOMA OF THE RETINA IN TUBEROUS SCLEROSIS
GIANT CELL ASTROCYTOMA OF THE RETINA IN TUBEROUS SCLEROSIS
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结节性硬化症视网膜巨细胞星形细胞瘤
DOI：
10.1097/00006982-199313020-00013
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
J. A. Staman
中科院分区：
文献类型：
--
作者：
C. Margo;J. Barletta;J. A. Staman
本文报告一例27岁女性结节性硬化症的临床及病理特征。肿瘤主要由大的多形性细胞和玻璃样嗜酸性细胞质组成。免疫染色γ烯醇化酶呈阳性结果，但没有胶质细胞酸性蛋白。该肿瘤的组织学和免疫病理学特征与结节性硬化症的室管膜下巨细胞星形细胞瘤基本相同。这个病例说明了结节性硬化症患者视网膜中发育不良的星形胶质细胞和神经元分化有很大的重叠。视网膜巨细胞星形细胞瘤在组织学上容易被不熟悉的人误认为恶性肿瘤。
The clinical and pathologic features of an unusual retinal glioma that was the only clinically overt manifestation of tuberous sclerosis in a 27-year-old woman are reported. The tumor was composed predominantly of large pleomorphic cells with glassy eosinophilic cytoplasm. Immunologic staining yielded positive results for gamma enolase, but not for glial fibrillary acid protein. The histologic and immunopathologic features of this tumor were essentially identical to the subependymal giant cell astrocytoma found in tuberous sclerosis. This case illustrates the large overlap in dysplastic astrocytic and neuronal differentiation that can occur in the retina of patients with tuberous sclerosis. Giant cell astrocytoma of the retina can be mistaken for a malignant tumor histologically by persons unfamiliar with this entity.