Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells.
Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells.
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DOI：
10.1194/jlr.r046094
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发表时间：
2014-05
影响因子：
6.5
通讯作者：
Shindou H
中科院分区：
文献类型：
--
作者：
Hishikawa D;Hashidate T;Shimizu T;Shindou H
细胞膜由多种甘油磷脂组成，其具有分别在sn-3位置的极性头和在sn-1和sn-2位置的酰基部分的不同组合。不同细胞类型、细胞器和内/外质膜小叶的甘油磷脂组合物是相当多样的。在从头途径中合成的甘油磷脂的酰基部分随后通过磷脂酶和溶血磷脂酰基转移酶的作用被重塑。这种重塑循环有助于膜甘油磷脂多样性的产生和脂质介质如脂肪酸衍生物和溶血磷脂的产生。此外，特定的甘油磷脂转运蛋白对于在每个细胞器中组织独特的甘油磷脂组合物也很重要。这一领域的最新进展有助于理解膜甘油磷脂多样性是如何组织和维持的。
Cellular membranes are composed of numerous kinds of glycerophospholipids with different combinations of polar heads at the sn-3 position and acyl moieties at the sn-1 and sn-2 positions, respectively. The glycerophospholipid compositions of different cell types, organelles, and inner/outer plasma membrane leaflets are quite diverse. The acyl moieties of glycerophospholipids synthesized in the de novo pathway are subsequently remodeled by the action of phospholipases and lysophospholipid acyltransferases. This remodeling cycle contributes to the generation of membrane glycerophospholipid diversity and the production of lipid mediators such as fatty acid derivatives and lysophospholipids. Furthermore, specific glycerophospholipid transporters are also important to organize a unique glycerophospholipid composition in each organelle. Recent progress in this field contributes to understanding how and why membrane glycerophospholipid diversity is organized and maintained.