A Homocoupling Approach to the Key Dione of CyMe4-BTPhen - Vital Ligands for Nuclear Clean-Up by the SANEX Process
A Homocoupling Approach to the Key Dione of CyMe4-BTPhen - Vital Ligands for Nuclear Clean-Up by the SANEX Process
复制标题
CyMe4-BTPhen 关键二酮的同偶联方法 - SANEX 工艺核净化的重要配体
作者：
Smith C
CyMe 4-BTPhen和CyMe 4-BTBP是欧洲用于分离锕系元素和镧系元素的主要配体系统，作为SANEX核回收和后处理工艺的一部分。我们提出了一种新的方法来合成的CyMe 4片段开始从容易获得的羟基新戊酸。它的特点是钴催化的新戊基溴的均偶联，以提供关键的双酯前体，从而避免了技术上具有挑战性的低温LDA介导的羟醛化学的要求。
CyMe4-BTPhen and CyMe4-BTBP are the principal ligand systems used in Europe for the separation of actinides from lanthanides as a part of the SANEX process for nuclear recycling and reprocessing. We present a new approach to the synthesis of the CyMe4fragment beginning from readily available hydroxypivalic acid. It features a cobalt-catalysed homocoupling of a neopentyl bromide to provide the key bisester precursor, thereby avoiding the requirement for technically challenging low-temperature LDA-mediated aldol chemistries.