Prefrontal Cortical Neurons Are Selective for Non-Local Hippocampal Representations during Replay and Behavior
Prefrontal Cortical Neurons Are Selective for Non-Local Hippocampal Representations during Replay and Behavior
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DOI：
10.1523/jneurosci.1158-20.2021
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发表时间：
2021-07-07
影响因子：
5.3
通讯作者：
Foster, David J.
中科院分区：
文献类型：
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作者：
Berners-Lee, Alice;Wu, Xiaojing;Foster, David J.
不同的功能，如决策和记忆巩固可能取决于海马（HP）和前额叶皮层（PFC）神经元之间的通信。HP重放是促进这种通信的候选机制，但是由于记录足够数量的HP神经元用于重放同时也记录PFC神经元的技术挑战，细节在很大程度上仍然未知。在这里，我们植入了40个四极驱动器，分为HP和PFC，在学习Y-迷宫空间记忆任务的雄性大鼠。令人惊讶的是，我们发现，在运动过程中的迷宫臂的非选择性，PFC神经元的一部分是高度选择性的HP重放不同的武器。此外，PFC神经元在跑步过程中对HP非局部手臂表征的选择性倾向于匹配其重放手臂选择性，并预测未来的选择。因此，PFC活动，调整到HP活动是最好的解释非本地HP的位置表示，而不是HP表示的实际位置，提供了一个新的潜在机制的HP-PFC的协调在HP重放。
Diverse functions such as decision-making and memory consolidation may depend on communication between neurons in the hippocampus (HP) and prefrontal cortex (PFC). HP replay is a candidate mechanism to facilitate this communication, however details remain largely unknown because of the technical challenges of recording sufficient numbers of HP neurons for replay while also recording PFC neurons. Here, we implanted male rats with 40-tetrode drives, split between HP and PFC, during learning of a Y-maze spatial memory task. Surprisingly, we found that in contrast to their non-selectivity for maze arm during movement, a portion of PFC neurons were highly selective for HP replay of different arms. Moreover, PFC neurons' selectivity to HP non-local arm representation during running tended to match their replay arm selectivity and was predictive of future choice. Thus, PFC activity that is tuned to HP activity is best explained by non-local HP position representations rather than HP representation of actual position, providing a new potential mechanism of HP-PFC coordination during HP replay.