Early markers of autism spectrum disorders in infants and toddlers prospectively identified in the Social Attention and Communication Study
Early markers of autism spectrum disorders in infants and toddlers prospectively identified in the Social Attention and Communication Study
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DOI：
10.1177/1362361312442597
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发表时间：
2013-01-01
期刊：
影响因子：
5.2
通讯作者：
Dissanayake, Cheryl
中科院分区：
文献类型：
--
作者：
Barbaro, Josephine;Dissanayake, Cheryl
社会关注和沟通研究涉及在社区环境中成功实施自闭症谱系障碍早期标志物的发育监测。本研究的目的是确定在 12、18 和 24 个月龄的社交注意力和沟通研究中使用的自闭症谱系障碍最具辨别力和预测性的标记，以便这些标记可用于更准确地识别患有自闭症谱系障碍的儿童。比较了 12 至 24 个月内患有自闭症 (n = 39)、自闭症谱系障碍 (n = 50) 和发育和/或语言迟缓 (n = 20) 的儿童对每个行为标记的“是/否”反应的百分比，并在 24 个月时进行了逻辑回归。在所有年龄段中，自闭症和自闭症谱系障碍反复出现的关键标志是目光接触和指向的缺陷，从 18 个月开始，表现缺陷成为一个重要标志。结合起来，这些行为以及假装游戏被发现是 24 个月时自闭症/自闭症谱系障碍最佳估计诊断分类的最佳预测因素。有人认为，社区卫生保健专业人员应在生命的第二年重复监测已确定的标记。
The Social Attention and Communication Study involved the successful implementation of developmental surveillance of the early markers of autism spectrum disorders in a community-based setting. The objective in the current study was to determine the most discriminating and predictive markers of autism spectrum disorders used in the Social Attention and Communication Study at 12, 18 and 24 months of age, so that these could be used to identify children with autism spectrum disorders with greater accuracy. The percentage of 'yes/no' responses for each behavioural marker was compared between children with autistic disorder (n = 39), autism spectrum disorder (n = 50) and developmental and/or language delay (n = 20) from 12 to 24 months, with a logistic regression also conducted at 24 months. Across all ages, the recurring key markers of both autistic disorder and autism spectrum disorder were deficits in eye contact and pointing, and from 18 months, deficits in showing became an important marker. In combination, these behaviours, along with pretend play, were found to be the best group of predictors for a best estimate diagnostic classification of autistic disorder/autism spectrum disorder at 24 months. It is argued that the identified markers should be monitored repeatedly during the second year of life by community health-care professionals.