Regional distribution of parkinsonism-preventing endogenous tetrahydroisoquinoline derivatives and an endogenous parkinsonism-preventing substance-synthesizing enzyme in monkey brain
Regional distribution of parkinsonism-preventing endogenous tetrahydroisoquinoline derivatives and an endogenous parkinsonism-preventing substance-synthesizing enzyme in monkey brain
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DOI：
10.1016/s0304-3940(99)00786-7
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发表时间：
1999-11-26
影响因子：
2.5
通讯作者：
Ohta, S
中科院分区：
文献类型：
--
作者：
Yamakawa, T;Kotake, Y;Ohta, S
1，2，3，4-四氢异喹啉（TIQ）和1-苄基-1，2，3，4-四氢异喹啉（1BnTIQ）是存在于多种哺乳动物脑中的帕金森病诱导物质，而1-甲基-1，2，3，4-四氢异喹啉（1 MeTIQ）是在大鼠脑中酶促合成的帕金森病预防物质。本研究检测了猴脑中TIQ、1 MeTIQ和1BnTIQ含量的区域分布以及1 MeTIQ合成酶的活性。大脑和黑质的TIQ和1BnTIQ含量以及纹状体和黑质的1 MeTIQ含量高于其他脑区，大脑和丘脑的1 MeTIQ合成活性较高。我们推测1 MeTIQ合成酶可能在特发性帕金森病中起重要作用。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
1,2,3,4-Tetrahydroisoquinoline (TIQ) and 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), which exist in the brain of several mammalian species, are parkinsonism-inducing substances, and 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), which is enzymatically synthesized in rat brain, is a parkinsonism-preventing substance. in this study, we examined the regional distribution of contents of TIQ, 1MeTIQ, and 1BnTIQ, and activity of 1MeTIQ-synthesizing enzyme in monkey brain. The TIQ and 1BnTIQ contents in cerebrum and substantia nigra, and the 1MeTIQ contents in striatum and substantia nigra were higher than those in other brain regions, and 1MeTIQ-synthetic activity was high in cerebrum and thalamus. We speculate that 1MeTIQ-synthesizing enzyme may play an important role in idiopathic Parkinson's disease. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.