The biology and chemistry of Epstein-Barr virus.
The biology and chemistry of Epstein-Barr virus.
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爱泼斯坦-巴尔病毒的生物学和化学。
DOI：
10.1093/infdis/146.4.506
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Heineman,T
中科院分区：
文献类型：
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作者：
Kieff,E;Dambaugh,T;Heller,M;King,W;Cheung,A;vanSanten,V;Hummel,M;Beisel,C;Fennewald,S;Hennessy,K;Heineman,T
EB病毒（EBV）是一个与旧世界灵长类动物密切相关的疱疹病毒家族的人类原型。这些病原体可能是在大约3000万年前猿类从猴子分化出来后在旧大陆灵长类动物中进化和传播的。虽然EBV家族的DNA与其他疱疹病毒没有序列同源性，但与其他疱疹病毒基因组有一些共同的特征。EBV DNA具有五个串联的直接重复元件，将基因组分成五个独特的序列结构域。在线性病毒体DNA末端的串联直接重复序列可能介导病毒DNA的环化以形成环状附加体病毒DNA，这是EBV感染细胞的特征。在潜伏性转化感染中，信使RNA由EBV基因组的三个广泛分离的区域编码。病毒基因组的其余部分编码许多在生产性感染中表达的RNA和蛋白质。早期和晚期病毒基因沿着EBV DNA的全长混合沿着。
Epstein-Barr virus (EBV) is the human prototype of a family of closely related herpesviruses of Old World primates. These agents probably evolved and spread among the Old World primates since the divergence of apes from monkeys about 30 million years ago. Although the DNAs of the EBV family have no sequence homology to other herpesviruses, there are some features in common with other herpesviral genomes. EBV DNA is unusual in having five tandem direct repeat elements which divide the genome into five unique sequence domains. The tandem direct repeats at the ends of the linear virion DNA probably mediate circularization of the viral DNA to form the circular episomal viral DNA which is characteristic of EBV-infected cells. In latent transforming infection, messenger RNAs are encoded by three widely separate regions of the EBV genome. The remainder of the viral genome encodes many RNAs and proteins which are expressed in productive infection. Early and late viral genes are intermixed along the full length of EBV DNA.