INSULIN RECEPTORS AND GLUCOSE UPTAKE IN THE HUMAN PARASITE SCHISTOSOMA MANSONI
INSULIN RECEPTORS AND GLUCOSE UPTAKE IN THE HUMAN PARASITE SCHISTOSOMA MANSONI
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DOI：
10.1051/parasite/2008154573
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发表时间：
2008-12-01
期刊：
影响因子：
2.9
通讯作者：
Dissous, C.
中科院分区：
文献类型：
--
作者：
Ahier, A.;Khayath, N.;Dissous, C.
尽管胰岛素信号在宿主-寄生虫分子对话和寄生虫生长发育中具有潜在的重要性，但人们对血吸虫中的胰岛素信号知之甚少。最近在曼氏血吸虫中两种胰岛素受体（SmIR-1和SmIR-2）的表征使我们重新考虑胰岛素在宿主-血吸虫相互作用中的潜在重要性。在这项工作中，我们证明了胰岛素可以调节血吸虫的葡萄糖摄取，并研究了SmIR-1和SmIR-2在这一过程中的作用。讨论了开发针对血吸虫的特异性SmIR-1和SmIR-2酪氨酸激酶活性抑制剂的可能性。
Very little is known about insulin signalling in schistosomes despite its potential importance in host-parasite molecular dialogue and parasite growth and development. The recent characterization of two insulin receptors (SmIR-1 and SmIR-2) in Schistosoma mansoni has led us to reconsider the question of the potential importance of insulin in host-schistosome interactions. In this work, we demonstrated that insulin could regulate glucose uptake in schistosomes and we investigated the implication of SmIR-1 and SmIR-2 in this process. The possibility that specific inhibitors of SmIR-1 and SmIR-2 tyrosine kinase activities could be developed to target schistosomes is discussed.