Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats
Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats
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DOI：
10.1016/j.febslet.2007.02.019
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发表时间：
2007-03-20
期刊：
影响因子：
3.5
通讯作者：
Oiso, Yutaka
中科院分区：
文献类型：
--
作者：
Banno, Ryoichi;Arima, Hiroshi;Oiso, Yutaka
In this study, we examined the effects of intracerebroventricular administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity in diet-induced obese (DIO) rats. Although MTII treatment significantly decreased food intake and body weight for 10 days, there was no significant difference in body weight between MTII and pair-fed groups. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MTII group compared to the pair-fed group. Furthermore, MTII treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MTII increased insulin sensitivity through action on the white adipose tissues in DIO rats. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
