Complete loss of the MHC II pathway in an anglerfish, Lophius piscatorius
Complete loss of the MHC II pathway in an anglerfish, Lophius piscatorius
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DOI：
10.1098/rsbl.2019.0594
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发表时间：
2019-10-01
期刊：
影响因子：
3.3
通讯作者：
Jakt, Lars Martin
中科院分区：
文献类型：
--
作者：
Dubin, Arseny;Jorgensen, Tor Erik;Jakt, Lars Martin
鱼类基因组研究为脊椎动物免疫系统的适应性提供了证据，揭示了替代免疫策略。据报道，缺乏的主要相容性复合物（MHC）II类途径的某些物种的海龙（属）和鳕鱼类鱼类（鳕形目）的组件是特别感兴趣的。MHC II途径负责通过将外源肽呈递给T辅助细胞来免疫和防御细胞外威胁。在这里，我们证明了编码MHC II组分（CD 4，CD 74 A/B，和经典和非经典的MHC II α/β）的基因组中的琵琶鱼，Lophius piscatorius的情况下，表明损失的MHC II途径。相比之下，先前有报道称另一种琵琶鱼，条纹琵琶鱼，保留了所有的MHC II基因，将Lophius分支中的MHC II基因丢失到它们最近的共同祖先。在三个分类群的MHC II损失已经发生，基因损失已被限制到四个或五个核心MHC II组件，这表明，在硬骨鱼，只有这些基因的功能，是限制在MHC II途径。
Genome studies in fish provide evidence for the adaptability of the vertebrate immune system, revealing alternative immune strategies. The reported absence of the major compatibility complex (MHC) class II pathway components in certain species of pipefish (genus Syngnathus) and cod-like fishes (order Gadiformes) is of particular interest. The MHC II pathway is responsible for immunization and defence against extracellular threats through the presentation of exogenous peptides to T helper cells. Here, we demonstrate the absence of all genes encoding MHC II components (CD4, CD74 A/B, and both classical and non-classical MHC II alpha/beta) in the genome of an anglerfish, Lophius piscatorius, indicating loss of the MHC II pathway. By contrast, it has previously been reported that another anglerfish, Antennarius striatus, retains all MHC II genes, placing the loss of MHC II in the Lophius clade to their most recent common ancestor. In the three taxa where MHC II loss has occurred, the gene loss has been restricted to four or five core MHC II components, suggesting that, in teleosts, only these genes have functions that are restricted to the MHC II pathway.