What We Have Learned: The Impact of Quality From a Clinical Trials Perspective
What We Have Learned: The Impact of Quality From a Clinical Trials Perspective
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DOI：
10.1016/j.semradonc.2011.09.004
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发表时间：
2012-01-01
影响因子：
3.5
通讯作者：
FitzGerald, Thomas J.
中科院分区：
文献类型：
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作者：
FitzGerald, Thomas J.
在这篇综述文章中，我们讨论了临床试验中放射肿瘤学过程的改进，并回顾了这些变化如何提高下一代试验的质量。近年来，我们已经从有限的数据采集到现在，我们有实时的临床试验质量的影响。这使得所有试验研究者能够立即获得重要的要素，包括分期、合格性、缓解和结局。现代信息学平台是为未来的适应性临床试验而设计的。我们回顾了当前和未来临床试验的信息学架构中所需要的内容。Semin Radiat Oncol 22：18-28（C）2012 Elsevier Inc. All rights reserved.
In this review article, we address the radiation oncology process improvements in clinical trials and review how these changes improve the quality for the next generation of trials. In recent years, we have progressed from a time of limited data acquisition to the present in which we have real-time influence of clinical trials quality. This enables immediate availability of the important elements, including staging, eligibility, response, and outcome for all trial investigators. Modern informatics platforms are well designed for future adaptive clinical trials. We review what will be needed in the informatics architecture of current and future clinical trials. Semin Radiat Oncol 22:18-28 (C) 2012 Elsevier Inc. All rights reserved.