Analysis of low-dose estrogen on callus BMD as measured by pQCT in postmenopausal women.
Analysis of low-dose estrogen on callus BMD as measured by pQCT in postmenopausal women.
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DOI：
10.1186/s12891-020-03713-4
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发表时间：
2020-10-19
影响因子：
2.3
通讯作者：
Lehmann W
中科院分区：
文献类型：
--
作者：
Jäckle K;Kolb JP;Schilling AF;Schlickewei C;Amling M;Rueger JM;Lehmann W
骨质疏松症影响老年患者，不分性别。它的特点是由于骨微结构的缺陷重塑导致骨折风险增加。它特别影响绝经后妇女，因为她们的雌激素水平降低。动物的临床前研究表明，雌激素的丢失对骨愈合有负面影响，增加雌激素水平会导致更好的骨愈合。我们询问更年期患者增加雌激素水平是否对骨折后骨痂形成过程中的骨密度(BMD)有有益影响。为了研究雌激素是否对绝经后患者的骨痂骨密度有有益影响，我们对76例桡骨远端骨折患者进行了前瞻性双盲随机研究。雌激素治疗组31例(71.13 年±11.99)，未治疗对照组45例(75.62 年±10.47)。术前和术后6周分别用外周定量计算机断层扫描(PQCT)测定骨密度和皮质骨密度。在骨折处和未骨折臂的相应位置进行对比测量。我们发现，与临床前模型不同，雌激素治疗并没有改善人类患者的骨折愈合。此外，我们没有观察到患者的年龄依赖性骨组织丢失和持续的骨痂形成之间的相关性。对绝经后妇女经皮应用雌激素，导致雌激素水平与绝经前妇女全身水平相似，但正如最近临床前动物模型所显示的那样，pQCT对骨痂BMD没有显著的有利影响。小剂量雌激素对绝经后妇女骨折愈合的pQCT检测没有显著影响。2019年11月25日注册-追溯注册。试验注册号为DRKS00019858。网上版载有补充材料，可在10.1186/s12891-020-03713-4查阅。
Osteoporosis affects elderly patients of both sexes. It is characterized by an increased fracture risk due to defective remodeling of the bone microarchitecture. It affects in particular postmenopausal women due to their decreased levels of estrogen. Preclinical studies with animals demonstrated that loss of estrogen had a negative effect on bone healing and that increasing the estrogen level led to a better bone healing. We asked whether increasing the estrogen level in menopausal patients has a beneficial effect on bone mineral density (BMD) during callus formation after a bone fracture. To investigate whether estrogen has a beneficial effect on callus BMD of postmenopausal patients, we performed a prospective double-blinded randomized study with 76 patients suffering from distal radius fractures. A total of 31 patients (71.13 years ±11.99) were treated with estrogen and 45 patients (75.62 years ±10.47) served as untreated controls. Calculated bone density as well as cortical bone density were determined by peripheral quantitative computed tomography (pQCT) prior to and 6 weeks after the surgery. Comparative measurements were performed at the fractured site and at the corresponding position of the non-fractured arm. We found that unlike with preclinical models, bone fracture healing of human patients was not improved in response to estrogen treatment. Furthermore, we observed no dependence between age-dependent bone tissue loss and constant callus formation in the patients. Transdermally applied estrogen to postmenopausal women, which results in estrogen levels similar to the systemic level of premenopausal women, has no significant beneficial effect on callus BMD as measured by pQCT, as recently shown in preclinical animal models. Low dose estrogen has no significant effect on bone fracture healing measured by pQCT in postmenopausal women, DRKS00019858. Registered 25th November 2019 - Retrospectively registered. Trial registration number DRKS00019858. The online version contains supplementary material available at 10.1186/s12891-020-03713-4.
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DOI：
10.1097/ta.0b013e3181c4544d
发表时间：
2010-11-01
影响因子：
--
作者：
Beil, Frank Timo;Barvencik, Florian;Amling, Michael
通讯作者：
Amling, Michael
影响因子：
2.4
作者：
Kreipke, Tyler C.;Garrison, Jacqueline G.;Niebur, Glen L.
通讯作者：
Niebur, Glen L.
影响因子：
4.2
作者：
Haffner-Luntzer M;Fischer V;Prystaz K;Liedert A;Ignatius A
通讯作者：
Ignatius A
影响因子：
6.2
作者：
Cao, YP;Mori, S;Norimatsu, H
通讯作者：
Norimatsu, H
影响因子：
1.9
作者：
Lee, Jung Il;Park, Ki Chul;Park, Jong Woong
通讯作者：
Park, Jong Woong