CLINICAL IMMUNITY IN ACUTE GASTROENTERITIS CAUSED BY NORWALK AGENT
CLINICAL IMMUNITY IN ACUTE GASTROENTERITIS CAUSED BY NORWALK AGENT
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DOI：
10.1056/nejm197707142970204
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发表时间：
1977-01-01
影响因子：
158.5
通讯作者：
BLACKLOW, NR
中科院分区：
文献类型：
--
作者：
PARRINO, TA;SCHREIBER, DS;BLACKLOW, NR
为检测病毒性胃肠炎的免疫功能，对12名志愿者进行了诺沃克（Norwalk）抗原攻毒和再攻毒后的症状、空肠活检和血清抗体水平的检测。第1次攻毒时，6名志愿者发生胃肠炎，但其他志愿者未发生。27-42个月时再次激发。后来，6名最初患病的志愿者再次患上胃肠炎并出现空肠病变; 6名先前免疫的志愿者没有出现疾病或空肠病变。在5名患病的志愿者中，4名在两次激发后血清诺瓦克因子抗体升高。3名免疫志愿者在两次攻毒后血清抗体均未升高。四名志愿者两次生病，在第二次生病后4-8周进行第三次挑战。1例发生胃肠炎，3例未发生。这些发现表明病毒性胃肠炎有两种免疫形式，一种是短期免疫，另一种是长期免疫。除血清抗体外，其他因素在免疫中起重要作用。
To examine immunity in viral gastroenteritis, 12 volunteers were challenged and then rechallenged with Norwalk agent, after which their symptoms, jejunal biopsies and serum antibody levels were examined. With the 1st challenge, gastroenteritis developed in 6 volunteers but not in the others. When rechallenged 27-42 mo. later, the 6 who became ill initially, again had gastroenteritis with jejunal lesions; in the 6 previously immune volunteers illness or jejunal lesions did not develop. Of 5 ill volunteers, 4 had increases in serum antibody to Norwalk agent ater both challenges. Serum antibody did not increase in 3 immune volunteers after either challenge. Four volunteers who had twice become ill, underwent a 3rd challenge 4-8 wk after their 2nd illness. In 1 gastroenteritis developed; in 3, it did not. These findings indicate 2 forms of immunity for viral gastroenteritis, one of short and the other of long duration. Factors other than serum antibody appear important in immunity to Norwalk gastroenteritis.