Cortical pattern of reduced perfusion in hearing loss revealed by ASL-MRI
Cortical pattern of reduced perfusion in hearing loss revealed by ASL-MRI
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DOI：
10.1002/hbm.24538
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发表时间：
2019-06-01
影响因子：
4.8
通讯作者：
Esposito, Fabrizio
中科院分区：
文献类型：
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作者：
Ponticorvo, Sara;Manara, Renzo;Esposito, Fabrizio
年龄相关性听力损失（HL）可能与脑功能障碍或结构损伤有关，并可能导致脑代谢/灌注异常。动脉自旋标记（ASL）磁共振成像（MRI）允许研究无创脑灌注变化。对31例HL（年龄范围47-77岁，平均年龄+/- SD = 63.4 +/- 8.4岁，纯音平均[PTA] HL > 50 dB）和28例听力正常（NH；年龄范围48-78岁，平均年龄+/- SD = 59.7 +/- 7.4岁）受试者进行假连续ASL、t1加权MRI （3 T）和神经心理测试（蒙特利尔认知评估）。分析脑血流（CBF）和灰质体积（GMV）在皮质体积上的差异，以评估灌注和结构组的差异。两名表现出认知障碍的HL受试者被排除在组比较之外。两组间在整体或局部萎缩方面均无显著差异，但HL组表现出双侧初级听觉皮层灌注减少的显著区域性影响，其中右侧Heschl’s gyrus CBF差异最大（-17.2%）。在HL和NH全样本（n = 59 = 31 HL + 28 NH）中，区域CBF与区域GMV呈正相关（p = 0.020）。在HL受试者（n = 31）中，区域CBF与听力图陡度呈负相关（频率范围：2-4 kHz，右耳：p = 0.022，左耳：p = 0.015）。皮层灌注减少模式提示在识别脑结构损伤之前，神经元代谢可能与HL有关。这也说明了ASL-MRI提供与HL相关的中枢加工减少的早期功能标记的潜力。
Age-related hearing loss (HL) can be related to brain dysfunction or structural damage and may result in cerebral metabolic/perfusion abnormalities. Arterial spin labeling (ASL) magnetic resonance imaging (MRI) allows investigating noninvasively brain perfusion changes. Pseudocontinuous ASL and T1-weighted MRI (at 3 T) and neuropsychological testing (Montreal Cognitive Assessment) were performed in 31 HL (age range = 47-77 years, mean age +/- SD = 63.4 +/- 8.4 years, pure-tone average [PTA] HL > 50 dB) and 28 normal hearing (NH; age range = 48-78 years, mean age +/- SD = 59.7 +/- 7.4 years) subjects. Cerebral blood flow (CBF) and gray matter volume (GMV) were analyzed in the cortical volume to assess perfusion and structural group differences. Two HL subjects showing cognitive impairment were excluded from group comparisons. No significant differences in either global or local atrophy were detected between groups but the HL group exhibited significant regional effects of reduced perfusion within the bilateral primary auditory cortex, with maximal CBF difference (-17.2%) in the right lateral Heschl's gyrus. For the whole sample of HL and NH subjects (n = 59 = 31 HL + 28 NH), the regional CBF was correlated positively to the regional GMV (p = 0.020). In HL subjects (n = 31), the regional CBF was correlated negatively to the audiogram steepness (frequency range: 2-4 kHz, right ear: p = 0.022, left ear: p = 0.015). The observed cortical pattern of perfusion reduction suggests that neuronal metabolism can be related to HL before the recognition of brain structural damage. This also illustrates the potential of ASL-MRI to contribute early functional markers of reduced central processing associated with HL.