Oxidative Stress and Inflammation Differentially Elevated in Objective Versus Habitual Subjective Reduced Sleep Duration in Obstructive Sleep Apnea
Oxidative Stress and Inflammation Differentially Elevated in Objective Versus Habitual Subjective Reduced Sleep Duration in Obstructive Sleep Apnea
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DOI：
10.5665/sleep.5964
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发表时间：
2016-07-01
期刊：
影响因子：
5.6
通讯作者：
Mehra, Reena
中科院分区：
文献类型：
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作者：
DeMartino, Theresanne;El Ghoul, Rawad;Mehra, Reena
研究目标：数据表明睡眠不足会对健康产生不利影响。我们假设氧化应激和全身炎症生物标志物会随着短期和长期睡眠时间的减少而升高。方法：我们分析了一项随机对照试验的基线检查数据，该试验涉及中度至重度阻塞性睡眠呼吸暂停 (OSA) 的参与者。基线多导睡眠图提供总睡眠时间（PSG-TST，主要预测因子）；收集自我报告的习惯性睡眠持续时间（SR-HSD）数据。氧化应激和全身炎症的早晨测量包括：髓过氧化物酶（MPO，pmol/L）、氧化低密度脂蛋白（ox-LDL，U/L）、F2-异前列腺素（ng/mg）、对氧磷酶1（PON1，nmol.min（-1）.mL（-1））和芳基酯酶（mu mol.min（-1）.mL（-1））。使用针对年龄、性别、种族、体重指数 (BMI)、心血管疾病 (CVD)、吸烟、他汀类药物/抗炎药物和呼吸暂停低通气指数进行调整的线性模型（β 估计值和 95% 置信区间）。 结果：最终分析样本由 147 名参与者组成；他们总体上是中年人（51.0 +/- 11.7 岁）、肥胖（BMI = 37.3 +/- 8.1 kg/m(2)），17% 患有心血管疾病。多变量模型证明 PSG-TST 和 MPO 呈显着负相关（β [95% CI] = -20.28 [-37.48，-3.08]，P = 0.021），即每小时增加 PSG-TST 减少 20.3 pmol/L MPO。或者，观察到与 ox-LDL 和 SR-HSD 呈显着负相关（β [95% CI] = 0.98 [0.96, 0.99]，P = 0.027），即 SR-HSD 每小时增加 2% ox-LDL 减少。 结论：即使在考虑肥胖和 OSA 严重程度后，仍观察到显着的负相关发现，即 PSG-TST 减少与 MPO 水平升高相关， SR-HSD 与 ox-LDL，表明急性与慢性睡眠不足中氧化应激和炎症途径的上调存在差异。
Study Objectives: Data have demonstrated adverse health effects of sleep deprivation. We postulate that oxidative stress and systemic inflammation biomarkers will be elevated in relation to short-term and long-term sleep duration reduction.Methods: We analyzed data from the baseline examination of a randomized controlled trial involving participants with moderate to severe obstructive sleep apnea (OSA). Baseline polysomnography provided the total sleep time (PSG-TST, primary predictor); self-reported habitual sleep duration (SR-HSD) data was collected. Morning measures of oxidative stress and systemic inflammation included: myeloperoxidase (MPO, pmol/L), oxidized low-density lipoprotein (ox-LDL, U/L), F2-isoprostane (ng/mg), paraoxonase 1 (PON1, nmol.min(-1).mL(-1)), and aryl esterase (mu mol.min(-1).mL(-1)). Linear models adjusted for age, sex, race, body mass index (BMI), cardiovascular disease (CVD), smoking, statin/anti-inflammatory medications, and apnea-hypopnea index were utilized (beta estimates and 95% confidence intervals).Results: One hundred forty-seven participants comprised the final analytic sample; they were overall middle-aged (51.0 +/- 11.7 y), obese (BMI = 37.3 +/- 8.1 kg/m(2)), and 17% had CVD. Multivariable models demonstrated a significant inverse association of PSG-TST and MPO (beta [95% CI] = -20.28 [-37.48, -3.08], P = 0.021), i.e., 20.3 pmol/L MPO reduction per hour increase PSG-TST. Alternatively, a significant inverse association with ox-LDL and SR-HSD was observed (beta [95% CI] = 0.98 [0.96, 0.99], P = 0.027), i.e., 2% ox-LDL reduction per hour increase SR-HSD.Conclusions: Even after consideration of obesity and OSA severity, inverse significant findings were observed such that reduced PSG-TST was associated with elevated MPO levels and SR-HSD with ox-LDL, suggesting differential up-regulation of oxidative stress and pathways of inflammation in acute versus chronic sleep curtailment.