Antihyperglycemic and antioxidative effect of hydro - methanolic (2:3) extract of the seed of Swietenia mahagoni (L.) Jacq. in streptozotocin-induced diabetic male albino rat: An approach through pancreas
Antihyperglycemic and antioxidative effect of hydro - methanolic (2:3) extract of the seed of Swietenia mahagoni (L.) Jacq. in streptozotocin-induced diabetic male albino rat: An approach through pancreas
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Swietenia mahagoni (L.) Jacq 种子氢甲醇 (2:3) 提取物的降血糖和抗氧化作用。
DOI：
10.1016/j.gmbhs.2012.11.001
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
D. Ghosh
中科院分区：
文献类型：
--
作者：
T. Bera;K. Chatterjee;Kishalay Jana;K. M. Ali;D. De;S. Maiti;D. Ghosh
本研究的目的是考察马哈根种子乙醇(2：3)提取液的药效。雅各布用于链脲佐菌素(STZ)诱导的糖尿病的治疗。将Wistar大鼠平均分为4组(n=6)：正常对照组、糖尿病对照组、糖尿病+二甲双胍治疗组和糖尿病+二甲双胍治疗组。提取物(25 mg/100 mg体重)和二甲双胍(2.5 mg/100 mg体重)每日一次，在禁食条件下灌胃21天。测定肝组织己糖激酶、葡萄糖-6-磷酸脱氢酶和葡萄糖-6-磷酸酶的活性。测定肝、肾组织中过氧化氢酶(CAT)、过氧化物酶(Px)、超氧化物歧化酶(SOD)活性以及硫代巴比妥酸反应物质(TBARS)和共轭二烯(CD)的含量。胰腺的组织结构和血清胰岛素水平也被评估。与对照组相比，STZ诱导的糖尿病大鼠肝组织己糖激酶和葡萄糖-6-磷酸脱氢酶活性显著降低，葡萄糖-6-磷酸酶显著升高。糖尿病动物空腹血糖(FBG)升高。糖尿病动物的CAT、Px和SOD活性随着血清总胆红素和镉水平的升高而显著降低。糖尿病动物的胰岛直径、胰岛计数和胰腺腺泡变性也被记录下来。用提取物或二甲双胍处理这些动物后，上述生物传感器基本恢复到对照水平。这种回收不等于二甲双胍，因为植物提取物不是有效成分(S)的纯形式，但为制药行业提供了洞察力，即提取物通过？细胞再生能力对糖尿病具有保护治疗作用。
The goal of this study was to investigate the effects of the hydro - methanolic (2:3) extract of the seed ofSwietenia mahagoni(L.) Jacq. for the management of streptozotocin (STZ)-induced diabetes. Wistar rats were divided equally into four groups (n = 6): normal control, diabetes control, diabetes + extract treated, and diabetes + metformin treated. The extract (25 mg/100 g by weight) and metformin (2.5 mg/100 g by weight) were administered once a day, orally by gavages for 21 days at fasting condition. Hexokinase, glucose-6-phosphate dehydrogenase, and glucose-6-phosphatase activities were measured in hepatic tissue. Activities of catalase (CAT), peroxidase (Px), and superoxide dismutase (SOD), along with the quantity of thiobarbituric acid reactive substances (TBARS) and conjugated diene (CD) in hepatic and renal tissues, were assessed. Histoarchitecture of the pancreas and serum insulin level were also evaluated. Significant diminution in the activities of hepatic hexokinase and glucose-6-phosphate dehydrogenase along with elevation in glucose-6-phosphatase were noted in STZ-induced animals with diabetes in respect to control animals. Level of fasting blood glucose (FBG) was elevated in animals with diabetes. Activities of CAT, Px, and SOD were diminished significantly along with the elevation in TBARS and CD levels in animals with diabetes. Diameter of pancreatic islets, count of islets, and degeneration in pancreatic acini were also noted in animals with diabetes. Treatment of these animals with extract or metformin resulted in substantial recovery in the aforementioned biosensors toward the control level. This recovery is not equal to metformin because the plant extract is not the pure form of effective ingredient(s) but provides insight to the pharmaceutical industries that the extract has a protective therapeutic effect against diabetes through ß-cell regeneration capacity.
影响因子：
2.5
作者：
Kimura, K;Spate, LD;Roberts, RM
通讯作者：
Roberts, RM