USE OF BACTERIAL INTERFERENCE TO CONTROL A STAPHYLOCOCCAL NURSERY OUTBREAK - DELIBERATE COLONIZATION OF ALL INFANTS WITH 502A STRAIN OF STAPHYLOCOCCUS ARUEUS
USE OF BACTERIAL INTERFERENCE TO CONTROL A STAPHYLOCOCCAL NURSERY OUTBREAK - DELIBERATE COLONIZATION OF ALL INFANTS WITH 502A STRAIN OF STAPHYLOCOCCUS ARUEUS
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DOI：
10.1001/archpedi.1967.02090180051001
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发表时间：
1967-01-01
影响因子：
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通讯作者：
BRACKVOGEL, V
中科院分区：
文献类型：
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作者：
LIGHT, IJ;WALTON, RL;BRACKVOGEL, V
通过将先前描述的相对/低致病性凝固酶阳性葡萄球菌（502A）定殖给所有婴儿，成功地控制了一种金黄色葡萄球菌致病性菌株（80/81）的托儿所暴发。在含青霉素和不含青霉素的培养基上对鼻腔和脐部部位进行培养，结果表明，在同一部位定植502A菌株的婴儿很少携带其他凝固酶阳性葡萄球菌。在接种的婴儿中，脓疱病变发生率低（小于5%），病变性质轻微，证实了502A菌株的低毒力。接种的微生物越多，病变发生的频率越高。在人员中，致病性葡萄球菌的许多鼻腔携带者是短暂携带者，当致病性葡萄球菌从婴儿身上消失时就失去了致病性菌株。一步一步的描述实验室程序和定植方法提出。
A nursery outbreak of a pathogenic strain of Staphylococcus aureus (80/81) was successfully controlled by purposely colonizing all infants with a previously described coagulase-positive Staphylococcus of relatively/ low pathogenicity (502A). Cultures from the nasal and umbilical sites streaked on media with and without penicillin demonstrated that infants colonized with the 502A strain rarely harbor other coagulase-positive staphylococci at the same site. Among the inoculated infants, the low incidence of pustular lesions (less than 5%) and the minor nature of the lesions confirmed the low virulence of the 502A strain. Lesions occurred more frequently when more organisms were inoculated. Among the personnel, many of the nasal carriers of pathogenic staphylococci were transient carriers and lost the pathogenic strain when it disappeared from the infants. A step-by-step description of the laboratory procedures and method of colonization is presented.