Differences in immune functions between human T-lymphotropic virus type I carriers and patients with adult T-cell leukemia/lymphoma
Differences in immune functions between human T-lymphotropic virus type I carriers and patients with adult T-cell leukemia/lymphoma
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DOI：
10.1006/clin.1996.0131
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发表时间：
1996-09-01
期刊：
影响因子：
--
通讯作者：
Kohashi, O
中科院分区：
文献类型：
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作者：
Funai, N;Shimamoto, Y;Kohashi, O
比较了人嗜t淋巴病毒I型（HTLV-I）携带者与成人t细胞白血病/淋巴瘤（ATL）患者的各项免疫指标。ATL患者淋巴细胞对刀豆蛋白A和植物血凝素的有丝分裂反应降低，而携带者和ATL患者淋巴细胞对美洲商陆有丝分裂原的反应与htlv - 1血清阴性对照相比有所降低。结核菌素阳性反应在携带者中与对照组一样频繁，但在ATL患者中较少。在从携带者分离的单核细胞中观察到嗜肺军团菌细胞内增殖的明显抑制，但在ATL患者或正常对照中没有。这些结果表明ATL患者具有严重的免疫缺陷，而HTLV-I携带者虽然在一定程度上受到免疫抑制，但在单核细胞中具有一定的抗微生物活性。(C) 1996学术出版社，Inc.
A variety of immunologic tests were compared between human T-lymphotropic virus type I (HTLV-I) carriers and patients with adult T-cell leukemia/ lymphoma (ATL). The mitogenic responses of the lymphocytes to concanavalin A and phytohemagglutinin were depressed in the ATL patients but not in the carriers, while the response to pokeweed mitogen in the carriers and ATL patients was depressed compared to the HTLV-I-seronegative controls. A positive tuberculin reaction in the carriers was as frequent as in the controls, but less frequent in the ATL patients. A marked inhibition of the intracellular multiplication of Legionella pneumophila was observed within the monocytes isolated from the carriers, but not in the ATL patients or the normal controls. These results indicate that the ATL patients have severe immunodeficiency, while the HTLV-I carriers have some activation of anti-microbial activity in monocytes although they are somewhat immunosuppressed. (C) 1996 Academic Press, Inc.