Mast cells correlate with angiogenesis and poor outcome in stage I lung adenocarcinoma
Mast cells correlate with angiogenesis and poor outcome in stage I lung adenocarcinoma
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DOI：
10.1034/j.1399-3003.2000.01517.x
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发表时间：
2000-06-01
影响因子：
24.3
通讯作者：
Abe, S
中科院分区：
文献类型：
--
作者：
Imada, A;Shijubo, N;Abe, S
血管生成部分与肥大细胞有关。然而，肥大细胞在肺癌中的生物学意义尚不清楚。采用免疫组化法对85例I期非小细胞肺癌的胰蛋白酶、CD34和血管内皮生长因子（VEGF）进行染色。在53例腺癌中的33例和32例鳞状细胞癌中的14例中发现VEGF。腺癌的肥大细胞计数明显高于鳞状细胞癌。在腺癌中，vegf阳性肿瘤的肥大细胞计数明显高于vegf阴性肿瘤，而鳞状细胞癌则不然。瘤内肥大细胞计数与微血管计数有良好的相关性。双染色显示大部分瘤内肥大细胞表达VEGF。重要的是，只有在肺腺癌中，高肥大细胞计数组患者的预后明显差于低肥大细胞计数组患者。结论：肿瘤释放的血管内皮生长因子可能与肥大细胞积聚有关，瘤内肥大细胞可能产生血管内皮生长因子，间质肥大细胞与I期肺腺癌血管生成和预后不良有关。
Angiogenesis is in part related to mast cells. However, the biological significance of mast cells within lung carcinoma remains unclear.Immunohistochemistry was used to stain for tryptase, CD34 and vascular endothelial growth factor (VEGF) in 85 cases of stage I nonsmall cell lung carcinoma.VEGF was found in 33 of 53 adenocarcinomas and 14 of 32 squamous cell carcinomas. Cases of adenocarcinoma had significantly higher mast cell counts than those of squamous cell carcinoma. In adenocarcinoma, mast cell counts in VEGF-positive tumours were significantly higher than in VEGF-negative tumours, whereas in squamous cell carcinoma they were not. Good correlation was observed between intratumoural mast cell counts and microvessel counts. Double staining showed most intratumoural mast cells expressed VEGF. Importantly, only in lung adenocarcinoma, members in the high mast cell count group had significantly worse prognosis than those in the low mast cell count group.It is concluded that tumour-released vascular endothelial growth factors may be related to mast cell accumulation, intratumoural mast cells may produce vascular endothelial growth factor, and stromal mast cells correlate with angiogenesis and poor outcome in stage I lung adenocarcinoma.