A long-lasting biological larvicide against the dengue vector mosquitoAedes albopictus
A long-lasting biological larvicide against the dengue vector mosquitoAedes albopictus
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DOI：
10.1002/ps.6069
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发表时间：
2020-09-17
影响因子：
4.1
通讯作者：
Chen, Xiao-Guang
中科院分区：
文献类型：
--
作者：
Liu, Tong;Xie, Yu-Gu;Chen, Xiao-Guang
BACKGROUND Aedes albopictusis the primary vector of mosquito-borne diseases, including dengue and chikungunya, in China. The management of vector mosquitoes is the primary strategy for the control of such infectious diseases. The gravidAe. albopictusprefers to skip-oviposit its eggs into different small water containers, and the management of these breeding places is critical for mosquito control. Bacillus thuringiensissubspeciesIsraelensis(Bti) is a useful biological larvicide, but the effective period of the currently available commercial product is relatively short. This study aimed to develop a long-lasting formulation of Bti to control the dengue vector mosquitoAe. albopictus. RESULTS Water-soluble polyethylene glycols and water-insoluble hexadecanol were mixed with Bti to develop the long-lasting formulation Bti-BLOCK, based on the solid dispersion technique. The controlled release of Bti-BLOCK and its effect onAe. albopictuswere assayed in the laboratory and in the field. The results showed that Bti toxins were slowly released from Bti-BLOCK into the water and maintained at an effective dose for at least 6 months. Bti-BLOCK caused high mortality during the immature stage (>90%) and achieved full inhibition during pupation (100%). The efficacy lasted at least 12 weeks in the laboratory and 6 weeks in the field. Furthermore, we confirmed an 89% reduction inAe. albopictusdensity and a reduction in theR(0)of dengue to a low-risk level after 6 months of open-field interventions. CONCLUSIONS We developed a long-lasting biological larvicide, Bti-BLOCK, which displayed very good efficacy in the control of the dengue vector mosquitoAe. albopictus.
