Effect of nerve cuff electrode geometry on onset response firing in high-frequency nerve conduction block.
Effect of nerve cuff electrode geometry on onset response firing in high-frequency nerve conduction block.
复制标题
神经袖带电极几何形状对高频神经传导阻滞中起始反应放电的影响。
DOI：
10.1109/tnsre.2010.2071882
复制
发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Kilgore KL
中科院分区：
文献类型：
--
作者：
Ackermann DM Jr;Bhadra N;Foldes EL;Wang XF;Kilgore KL
高频交流电的传递已被证明在整个神经中产生局灶性和可逆传导阻滞，是一种潜在的治疗各种疾病和涉及病理性或不受欢迎的神经活动的疾病的选择。然而，向神经输送高频交流电会在神经被阻断之前产生有限的神经元放电，称为起始反应。减少或消除起效反应对于将这种类型的神经阻滞应用于临床非常重要，因为起效反应可能导致不希望看到的肌肉收缩和疼痛。本文研究了神经袖带电极几何形状(具体地说，两极接触间隔距离)和波形幅度对起始性反应的幅度和持续时间的影响。电极几何形状和波形幅度都影响这些测量。起搏反应的幅度和持续时间与双极分离距离和波幅呈单调关系。对于不同电极几何形状和波形幅度的组合，起搏反应的持续时间平均差异高达820%。接触间隔为0.5 mm的双极电极平均起效时间最短。此外，这项研究中提供的数据为发病反应的生物物理解释提供了一些见解。这些数据表明，起搏反应由两个不同的阶段组成：一个阶段对电极几何形状和波形幅度等实验变量做出反应，另一个阶段不是而且似乎是向阻断状态的转变所固有的。本研究对临床治疗系统和基础神经生理学研究的神经阻断电极和刺激参数的选择具有一定的指导意义。
The delivery of high-frequency alternating currents has been shown to produce a focal and reversible conduction block in whole nerve and is a potential therapeutic option for various diseases and disorders involving pathological or undesired neurological activity. However, delivery of high-frequency alternating current to a nerve produces a finite burst of neuronal firing, called the onset response, before the nerve is blocked. Reduction or elimination of the onset response is very important to moving this type of nerve block into clinical applications since the onset response is likely to result in undesired muscle contraction and pain. This paper describes a study of the effect of nerve cuff electrode geometry (specifically, bipolar contact separation distance), and waveform amplitude on the magnitude and duration of the onset response. Electrode geometry and waveform amplitude were both found to affect these measures. The magnitude and duration of the onset response showed a monotonic relationship with bipolar separation distance and amplitude. The duration of the onset response varied by as much as 820% on average for combinations of different electrode geometries and waveform amplitudes. Bipolar electrodes with a contact separation distance of 0.5 mm resulted in the briefest onset response on average. Furthermore, the data presented in this study provide some insight into a biophysical explanation for the onset response. These data suggest that the onset response consists of two different phases: one phase which is responsive to experimental variables such as electrode geometry and waveform amplitude, and one which is not and appears to be inherent to the transition to the blocked state. This study has implications for nerve block electrode and stimulation parameter selection for clinical therapy systems and basic neurophysiology studies.