SUPPRESSIVE EFFECT OF MIZORIBINE ON HUMORAL ANTIBODY-PRODUCTION IN DBA/2 MICE
SUPPRESSIVE EFFECT OF MIZORIBINE ON HUMORAL ANTIBODY-PRODUCTION IN DBA/2 MICE
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DOI：
10.1097/00007890-198604000-00016
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发表时间：
1986-04-01
期刊：
影响因子：
6.2
通讯作者：
UCHIYAMA, T
中科院分区：
文献类型：
--
作者：
OKUBO, M;CHEN, XM;UCHIYAMA, T
用DBA/2小鼠研究咪唑立宾（MZR）作为B细胞抑制剂的作用方式。其体外给药通过抑制IgM抗体形成，显著延迟了血凝素产生对绵羊红细胞的主要反应。MZR剂量依赖性地抑制了体外噬斑形成细胞（PFC）对T依赖性和T非依赖性抗原（如TNP-SRBC和TNP-流产布鲁氏菌）的应答。由于脾细胞的T-耗竭部分的PFC形成同样受到抑制，MZR可能通过直接影响B细胞（和/或巨噬细胞）以及通过调节调节性T细胞来抑制体液抗体应答。MZR可能仅作用于抗原刺激后B淋巴细胞细胞周期的某个阶段。它可能不干扰初始抗原识别或成熟B细胞。
The mode of action of mizoribine (MZR) as a B cell inhibitor was studied using DBA/2 mice. Its in vitro administration significantly delayed the primary response in hemagglutinin production against sheep erythrocytes by suppressing the IgM antibody formation. In vitro plaque-forming cell (PFC) response against both T-dependent and T-independent antigens, such as TNP-SRBC and TNP-Brucella abortus, was dose-dependently suppressed by MZR. Since PFC formation by the T-depleted fraction of splenocytes was likewise suppressed, MZR may inhibit humoral antibody response by directly affecting the B cells (and/or macrophages) as well as by modulating the regulatory T cells. MZR may only act on a certain stage of the cell cycle of B lymphocytes following antigenic stimulation. It may not interfere with the initial antigen recognition or with mature B cells.