Central excitability contributes to supramaximal volitional contractions in human incomplete spinal cord injury.
Central excitability contributes to supramaximal volitional contractions in human incomplete spinal cord injury.
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中枢兴奋性有助于人类不完全脊髓损伤中的超最大意志收缩。
DOI：
10.1113/jphysiol.2011.212233
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Hornby,TGeorge
中科院分区：
文献类型：
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作者：
Thompson,ChristopherK;Lewek,MichaelD;Jayaraman,Arun;Hornby,TGeorge
Non‐technical summaryIndividuals with a motor incomplete spinal cord injury (SCI) present clinically with partial control of muscles below the site of the injury, but experience profound weakness which can limit the ability to perform functional tasks such as walking. Interestingly, when individuals with an incomplete SCI are asked to maximally and repeatedly contract their quadriceps muscles, they demonstrate anincreasein the peak force generated; individuals without SCI experience a decline in force, or ‘fatigue’. Following these repeated maximal efforts, reflex responses to electrical stimulation over the quadriceps muscle elicited amplified and prolonged, involuntary motor activity. Such responses were not observed prior to the maximal contractions, and were not observed in neurologically intact subjects. This finding suggests that increases in spinal excitability following these maximal efforts may enhance force generating capacity, and provides insight into possible novel therapeutic interventions to restore function following SCI.
