Flavonoid intake and cognitive decline over a 10-year period
Flavonoid intake and cognitive decline over a 10-year period
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DOI：
10.1093/aje/kwm036
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发表时间：
2007-06-15
影响因子：
5
通讯作者：
Barberger-Gateau, P.
中科院分区：
文献类型：
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作者：
Letenneur, L.;Proust-Lima, C.;Barberger-Gateau, P.
在PAQUID(Personnes Agees Quid)研究中，作者前瞻性地检查了65岁或65岁以上受试者中类黄酮类化合物的摄入量与认知功能和衰退的关系。共有1,640名在1990年基线时未患痴呆症且饮食评估可靠的受试者在10年内进行了四次复查。在每次就诊时，通过三项心理测量测试(简易精神状态检查、本顿视觉保持测试、“Isaacs”集合测试)评估认知功能。在基线时收集有关类黄酮摄入量的信息。用线性混合模型分析了类黄酮类摄入量四分位数对认知能力的影响。在调整了年龄、性别和教育水平后，类黄酮摄入与基线时更好的认知表现(p=0.019)和随时间推移的更好的认知表现(p=0.046)相关。类黄酮摄入量最高的两个四分位数的受试者比摄入量最低的四分位数的受试者有更好的认知进化。经过10年的随访，类黄酮类摄入量最低的受试者在简易智力状态检查中平均损失2.1分，而四分位数最高的受试者平均损失1.2分。在对其他几个潜在混杂因素进行调整后，这种梯度仍然存在。这项研究提出了这样一种可能性，即饮食中的类黄酮摄入量与更好的认知进化有关。
In the PAQUID (Personnes Agees Quid) study, the authors prospectively examined flavonoid intake in relation to cognitive function and decline among subjects aged 65 years or older. A total of 1,640 subjects free from dementia at baseline in 1990 and with reliable dietary assessment were reexamined four times over a 10-year period. Cognitive functioning was assessed through three psychometric tests (Mini-Mental State Examination, Benton's Visual Retention Test, "Isaacs" Set Test) at each visit. Information on flavonoid intake was collected at baseline. A linear mixed model was used to analyze the evolution of cognitive performance according to quartiles of flavonoid intake. After adjustment for age, sex, and educational level, flavonoid intake was associated with better cognitive performance at baseline (p = 0.019) and with a better evolution of the performance over time (p = 0.046). Subjects included in the two highest quartiles of flavonoid intake had better cognitive evolution than did subjects in the lowest quartile. After 10 years' follow-up, subjects with the lowest flavonoid intake had lost on average 2.1 points on the Mini-Mental State Examination, whereas subjects with the highest quartile had lost 1.2 points. This gradient persisted after adjustment for several other potential confounders. This study raises the possibility that dietary flavonoid intake is associated with better cognitive evolution.