Breastfeeding and Nutrition to 2 Years of Age and Risk of Childhood Acute Lymphoblastic Leukemia and Brain Tumors
Breastfeeding and Nutrition to 2 Years of Age and Risk of Childhood Acute Lymphoblastic Leukemia and Brain Tumors
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DOI：
10.1080/01635581.2015.998839
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发表时间：
2015-04-03
影响因子：
2.9
通讯作者：
Milne, Elizabeth
中科院分区：
文献类型：
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作者：
Greenop, Kathryn R.;Bailey, Helen D.;Milne, Elizabeth
急性淋巴细胞性白血病(ALL)和儿童脑瘤(CBT)是儿童癌症中最常见的两种形式，但对其病因知之甚少。在两个全国性的病例对照研究中，我们调查了母乳喂养、开始进食的年龄或早期饮食是否与这些癌症的风险有关。从2003年至2007年(ALL)和2005年至2010年(CBT)的澳大利亚儿科肿瘤科和通过全国随机数字拨号以人群为基础的对照中确定了0-14岁的病例。母亲们完成了关于婴儿喂养到2岁的详细情况的调查问卷。对322例ALL、679例ALL、299例CBT和733例CBT对照的资料进行了非条件Logistic回归分析。母乳喂养与ALL风险降低相关[优势比(OR)=0.52，95%可信区间(CI)：0.32，0.84]，与持续时间无关。出生14天内引入人工配方奶粉与ALL呈正相关(OR=1.57，95%CI：1.03，2.37)，纯配方奶粉喂养至6月龄与ALL呈正相关(OR=1.81，95%CI：1.07，3.05)。未发现母乳喂养或配方奶粉使用与CBT风险之间存在关联。我们的结果表明，母乳喂养和延迟引入人工配方奶粉可能会降低ALL而不是CBT的风险。
Acute lymphoblastic leukemia (ALL) and childhood brain tumors (CBT) are 2 of the most common forms of childhood cancer, but little is known of their etiology. In 2 nationwide case-control studies we investigated whether breastfeeding, age of food introduction, or early diet are associated with the risk of these cancers. Cases aged 0-14years were identified from Australian pediatric oncology units between 2003 and 2007 (ALL) and 2005 and 2010 (CBT) and population-based controls through nationwide random-digit dialing. Mothers completed questionnaires giving details of infant feeding up to the age of 2yr. Data from 322 ALL cases, 679 ALL controls, 299 CBT cases, and 733 CBT controls were analysed using unconditional logistic regression. Breastfeeding was associated with a reduced risk of ALL [odds ratio (OR) = 0.52, 95% confidence interval (CI): 0.32, 0.84), regardless of duration. Introduction of artificial formula within 14days of birth was positively associated with ALL (OR = 1.57, 95% CI: 1.03, 2.37), as was exclusive formula feeding to 6 mo (OR = 1.81, 95% CI: 1.07, 3.05). No associations were seen between breastfeeding or formula use and risk of CBT. Our results suggest that breastfeeding and delayed introduction of artificial formula may reduce the risk of ALL but not CBT.