Magnetic Resonance Imaging of Asians with Multiple Sclerosis was Similar to that of the West
Magnetic Resonance Imaging of Asians with Multiple Sclerosis was Similar to that of the West
复制标题
亚洲多发性硬化症患者的磁共振成像与西方人相似
DOI：
10.1017/s0317167100004777
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
C. Tan
中科院分区：
文献类型：
--
作者：
H. Chong;N. Ramli;K.H. Lee;B.J. Kim;M. Ursekar;K. Dayananda;B. Singhal;J. Chong;L. Chan;Y.Y. Seetoh;O. Chawalparit;N. Prayoonwiwat;F. Chang;C. Tsai;K. Tang;Pck Li;C. Tan
摘要：脑部磁共振成像（MRI）是多发性硬化症（MS）最重要的临床旁诊断检查。亚洲MS患者的MRI表现尚不明确。我们回顾性调查了第一次脑和脊髓MRI诊断为MS患者，根据Poser的标准，在整个亚洲的7个地区，以定义与MS的亚洲人之间的MRI变化。有101例患者的第一个大脑，和86与第一个脊髓MRI，其中66人都有。脑部MRI显示T2加权图像中每例患者平均有17个病变，大多数无症状。几乎所有的病变都位于白色物质，尤其是在前皮质、深部和脑室周围的白色物质。三分之一的病变大于5 mm，14%用钆增强。幕上病变多于幕下病变，比例为7.5：1。95%的脊髓病变位于颈胸区，34%的脊髓病变经钆增强。病变平均延伸至3.6 ± 3.3个椎体。50（50%）的大脑和54（63%）的脊柱MRI患者有MS的视神经脊髓形式。视神经脊髓和经典组患者的MRI在外观和分布上相似，除了视神经脊髓MS患者有更少的大脑，但更长，更严重的脊髓病变。总之，亚洲MS患者的脑和脊髓MRI与西方相似，尽管在本研究中，亚洲MS患者的脊髓病变较大。
ABSTRACT: Magnetic resonance imaging (MRI) of the brain is the most important paraclinical diagnostic test in multiple sclerosis (MS). The appearance of MRI in Asians with MS is not well defined. We retrospectively surveyed the first brain and spinal cord MRI in patients diagnosed to have MS, according to Poser's criteria in seven regions throughout Asia to define the MRI changes among Asians with MS. There were 101 patients with first brain, and 86 with first spinal cord MRI, 66 of whom had both. The brain MRI showed a mean of 17 lesions per patient in T2 weighted images, mostly asymptomatic. Almost all the lesions were in the white matter, particularly in the juxtacortical, deep and periventricular white matter. A third of the lesions were greater than 5 mm, 14% enhanced with gadolinium. There were more supratentorial than infratentorial lesions at a ratio of 7.5: 1. Ninety five percent of the spinal cord lesions were in cervical and thoracic regions, 34% enhanced with gadolinium. The lesions extended over a mean of 3.6 ± 3.3 vertebral bodies in length. Fifty (50%) of the brain and 54 (63%) of the spinal MRI patients had the optic-spinal form of MS. The MRI of the optic-spinal and classical groups of patients were similar in appearance and distribution, except that the optic-spinal MS patients have fewer brain but longer and more severe spinal cord lesions. In conclusion, the brain and spinal cord MRI of Asian patients with MS was similar to that of the West, although, in this study, Asian MS patients had larger spinal cord lesions.