Loss of Smad4 protein expression and 18qLOH as molecular markers indicating lymph node metastasis in colorectal cancer—a study matched for tumor depth and pathology
Loss of Smad4 protein expression and 18qLOH as molecular markers indicating lymph node metastasis in colorectal cancer—a study matched for tumor depth and pathology
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DOI：
10.1002/jso.20896
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发表时间：
2008
影响因子：
2.5
通讯作者：
Toshiaki Tanaka;Toshiaki Watanabe;Y. Kazama;J. Tanaka;T. Kanazawa;S. Kazama;H. Nagawa
中科院分区：
文献类型：
--
作者：
Toshiaki Tanaka;Toshiaki Watanabe;Y. Kazama;J. Tanaka;T. Kanazawa;S. Kazama;H. Nagawa
染色体18q21缺失和Smad4蛋白失活已被报道为预测结直肠癌不良结果的分子标志物，在之前的报告中，我们最近发现这些分子与远处转移密切相关，这是影响术后生存的临床因素之一。然而，目前还没有讨论这些分子如何影响另一个临床因素，即淋巴结转移。在本报告中，我们研究了染色体 18q 缺失和 Smad4 蛋白表达缺失与淋巴结转移相关的意义。
Chromosome 18q21 deletion and Smad4 protein inactivation have been reported as molecular markers predicting unfavorable outcome in colorectal cancers and, in a previous report, we recently revealed that these molecules are closely associated with distant metastasis, which is one of the clinical factors affecting postoperative survival. However, there has been no discussion as to how these molecules influence another clinical factor, namely, lymph node metastasis. In this report, we studied the significance of chromosome 18q deletion and loss of Smad4 protein expression in association with lymph node metastasis.