Quantitative evaluation of peripheral tissue elasticity for ultrasound-detected breast lesions
Quantitative evaluation of peripheral tissue elasticity for ultrasound-detected breast lesions
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超声检测乳腺病变周围组织弹性的定量评估
DOI：
10.1016/j.crad.2016.06.104
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发表时间：
2016-09-01
影响因子：
2.6
通讯作者：
Zheng, H.
中科院分区：
文献类型：
--
作者：
Xiao, Y.;Yu, Y.;Zheng, H.
目的：评价外周组织弹性定量测量在超声检查乳腺良恶性病变中的诊断价值。材料和方法：本研究由机构评审委员会批准，所有患者均签署知情同意书。自2012年6月至2014年4月，对205例(平均年龄41.9±12.3岁，年龄18~76岁)205个乳腺病变(恶性78个，良性127个)进行了常规B超和SWE检查。对于每个病变，通过使用计算机辅助工具构建其轮廓周围的边缘，包括足够的邻近周围组织。根据最终的组织病理学结果评估边缘的定量弹性图特征(弹性平均值、最大值、标准差和弹性比)以及乳房影像报告和数据系统(bi-RADS)的分类。通过敏感性、特异性、阳性预测值和阴性预测值以及受试者工作特征曲线分析，评价三组数据集的诊断性能。结果：乳腺良、恶性病变外周组织的SWE表现有显著差异(平均+/-标准差[SD]：弹性平均值，16.1+/-6.6比43.6+/-17.8；最大值，5 5.4+/-31.4比150.3+/-44.6；SD分别为8.1+/-4.1和30+/-13.8，弹性比分别为1.1+/-0.2和2+/-0.7，均P
AIM: To evaluate the diagnostic performance of the quantitative measurement of peripheral tissue elasticity using shear-wave elastography (SWE) in differentiating between benign and malignant breast lesions detected by ultrasonography (US).MATERIALS AND METHODS: This study was approved by institutional review board; informed consent was signed from all patients. From June 2012 to April 2014, conventional B mode US and SWE were performed in 205 breast lesions (78 malignant, 127 benign) of 205 consecutive women (mean age, 41.9 +/- 12.3 years; age range, 18-76 years). For each lesion, a rim around its contour was constructed by using a computer-aided tool, including adequate adjacent peripheral tissue. Quantitative elastographic features of the rim (elasticity mean, maximum, standard deviation, and elasticity ratio) as well as Breast Imaging Reporting and Data System.(BI-RADS) categories were assessed according to the final histopathological results. Sensitivity, specificity, positive and negative predictive values, and receiver operating characteristic (ROC) curve analysis were performed to evaluate the diagnostic performances for the three data sets (conventional B-mode US alone, SWE features alone, and combined B mode US and SWE features).RESULTS: SWE features of the peripheral tissue differed significantly between benign and malignant breast lesions (mean +/- standard deviation [SD]: elasticity mean, 16.1 +/- 6.6 versus 43.6 +/- 17.8; maximum, 55.4 +/- 31.4 versus 150.3 +/- 44.6; SD, 8.1 +/- 4.1 versus 30 +/- 13.8 and elasticity ratio, 1.1 +/- 0.2 versus 2 +/- 0.7, respectively, all p