Acceleration of the body clearance of phenobarbital by oral activated charcoal.
Acceleration of the body clearance of phenobarbital by oral activated charcoal.
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口服活性炭加速苯巴比妥的体内清除。
DOI：
10.1056/nejm198209093071102
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Johnson,GF
中科院分区：
文献类型：
--
作者：
Berg,MJ;Berlinger,WG;Goldberg,MJ;Spector,R;Johnson,GF
我们在随机交叉试验中研究了多剂量口服活性碳对静脉注射苯巴比妥的药代动力学的影响。六名健康男性志愿者分两次静脉注射每70公斤体重200毫克的苯巴比妥钠。有一次，在注射苯巴比妥后的三天内，每个受试者都服用了不同剂量的口服活性碳(180克)。所有受试者在输液后90小时内测定血清苯巴比妥水平，两名受试者在输液后24至96小时测定尿苯巴比妥排泄量。药代动力学分析表明，木炭使苯巴比妥的血清半衰期从110±8小时减少到45±6小时(S.E.M.)苯巴比妥总清除量由4.4±0.2增至12.0±1.6ml/kg/h(P<；0.01)，非肾清除量占总清除量的52%至80%。我们的结论是，口服活性炭能增强苯巴比妥的非肾脏清除。(英国医学杂志)1982年；307：642-4。)
We investigated the effect of multiple oral doses of activated charcoal on the pharmacokinetics of intravenously administered phenobarbital in a randomized crossover trial. Six healthy men volunteered to take 200 mg of phenobarbital sodium per 70 kg of body weight intravenously on two separate occasions. On one occasion, each subject received oral activated charcoal (180 g) in divided doses over three days after the infusion of phenobarbital. Serum levels of phenobarbital were measured in all subjects up to 90 hours after the infusion, and urinary excretion of phenobarbital was measured in two subjects 24 to 96 hours after the infusion. A pharmacokinetic analysis showed that the charcoal decreased the serum half-life of phenobarbital from 110±8 to 45±6 hours (S.E.M.) (P<0.01), increased the total body clearance of phenobarbital from 4.4±0.2 to 12.0±1.6 ml per kilogram per hour (P<0.01), and increased the nonrenal clearance from 52 to 80 per cent of the total body clearance. We conclude that oral administration of activated charcoal enhances the nonrenal clearance of phenobarbital. (N Engl J Med. 1982; 307:642–4.)