Estrogen regulates the IFN-gamma promoter.
Estrogen regulates the IFN-gamma promoter.
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DOI：
10.4049/jimmunol.146.12.4362
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发表时间：
1991-06
影响因子：
4.4
通讯作者：
H. Fox;B. Bond;T. Parslow
中科院分区：
文献类型：
--
作者：
H. Fox;B. Bond;T. Parslow
女性的免疫反应性更强，部分原因是性类固醇激素的影响，但其潜在机制尚不清楚。在这里，我们报告的证据表明，IFN-γ基因的表达可能受到直接的激素控制。在瞬时表达试验中，性类固醇17 β-雌二醇显著增加表达适当激素受体的淋巴细胞中IFN-γ启动子的活性。这种作用是由基因的5 '侧翼区的序列介导的，并且可以增强T细胞活化剂的作用。短期暴露于雌二醇也增加IFN-γ mRNA的表达在Con A处理的小鼠脾细胞。这种多效性细胞因子的激素调节可能部分地解释了雌激素增强多种类型的免疫应答的能力，以及女性对自身免疫性疾病的不成比例的易感性。
The greater immune reactivity of females has been attributed in part to the influence of sex steroid hormones, but the underlying mechanisms are unknown. Here we report evidence that expression of the IFN-gamma gene may be subject to direct hormonal control. In a transient expression assay, the sex steroid 17 beta-estradiol markedly increases activity of the IFN-gamma promoter in lymphoid cells that express the appropriate hormone receptor. This effect is mediated by sequences in the 5'-flanking region of the gene, and can augment the effect of T cell-activating agents. Short term exposure to estradiol also increases IFN-gamma mRNA expression in Con A-treated murine spleen cells. Hormonal regulation of this pleiotropic cytokine may account in part for the ability of estrogen to potentiate many types of immune responses, and for the disproportionate susceptibility of females to autoimmune disease.