Antiretroviral therapy effects on sources of cortical rhythms in HIV subjects: Responders vs. Mild Responders
Antiretroviral therapy effects on sources of cortical rhythms in HIV subjects: Responders vs. Mild Responders
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DOI：
10.1016/j.clinph.2014.03.036
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发表时间：
2015-01-01
影响因子：
4.7
通讯作者：
Andreoni, Massimo
中科院分区：
文献类型：
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作者：
Babiloni, Claudio;Pennica, Alfredo;Andreoni, Massimo
目的：我们验证了5个月的联合抗逆转录病毒治疗（cART）对初发HIV患者静息状态皮质脑电图（EEG）节律的皮层源的影响。方法：记录38例初次感染HIV的患者在基线（即治疗前；T0）、T1 （cART治疗4周后）、T2 （cART治疗8周后）和T5 （cART治疗5个月后）闭眼静息状态脑电图数据。作为对照，还记录了40名年龄匹配的认知正常受试者的脑电图数据。感兴趣的脑电图节律为delta （2-4 Hz）、theta （4-8 Hz）、alpha 1 （8-10.5 Hz）、alpha 2 （10.5-13 Hz）、beta 1 （13-20 Hz）和beta 2 （20-30 Hz）。采用LORETA软件对皮质脑电源进行估计。结果：与对照组相比，HIV组在T0时表现出更大的δ源和更低的广泛α源。cART诱导生物（病毒载量，CD4计数）和脑电图（δ, α）标志物的整体改善，即使在4周后也显着。与HIV应答者（随访5个月时为100个细胞/ μ l）相比，HIV轻度应答者(
Objective: We tested the hypothesis that 5 months of combined anti-retroviral therapy (cART) affect cortical sources of resting state cortical electroencephalographic (EEG) rhythms in naive HIV subjects.Methods: Eyes-closed resting state EEG data were recorded at baseline (i.e. pre-treatment; T0), T1 (after 4 weeks of cART), T2 (after 8 weeks of cART), and T5 (after 5 months of cART) in 38 naive HIV subjects. EEG data were also recorded in 40 age-matched cognitively normal subjects for control purposes. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). Cortical EEG sources were estimated by LORETA software.Results: Compared to the control group, the HIV group at T0 showed greater delta sources and lower widespread alpha sources. cART induced a global improvement of biological (viral load, CD4 count) and EEG (delta, alpha) markers, remarkable even after 4 weeks. Compared to HIV Responders (>100 cells/mu l at 5-month follow up), the HIV Mild Responders (