Effect of Roux-en-y Gastric Bypass on Nonalcoholic Fatty Liver Disease Evaluated Through NAFLD Fibrosis Score: a Prospective Study
Effect of Roux-en-y Gastric Bypass on Nonalcoholic Fatty Liver Disease Evaluated Through NAFLD Fibrosis Score: a Prospective Study
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DOI：
10.1007/s11695-014-1489-2
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发表时间：
2015-06-01
期刊：
影响因子：
2.9
通讯作者：
Chaim, Elinton Adami
中科院分区：
文献类型：
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作者：
Cazzo, Everton;Jimenez, Laisa Simakawa;Chaim, Elinton Adami
非酒精性脂肪性肝病（NAFLD）在接受减肥手术的受试者中很常见，并且有报告称其术后改善。本研究旨在通过术后12个月的NAFLD纤维化评分来确定肝脏疾病的进展。这是一项前瞻性队列研究，评估了Roux-en-Y胃旁路术（RYGB）前和术后12个月的患者。平均评分从1.142降至0.066;手术导致晚期纤维化的消退率为55%。在统计学上，RYGB的消退与女性性别、体重过度减轻的百分比、术后体重指数、术后血小板计数和糖尿病消退有关。由于术后活检并不广泛可用，并且具有显著的风险，因此计算NAFLD纤维化评分是通过无创方法评估这种演变的简单工具。
Nonalcoholic fatty liver disease (NAFLD) is common among subjects who undergo bariatric surgery and its postsurgical improvement has been reported. This study aimed to determine the evolution of liver disease evaluated through NAFLD fibrosis score 12 months after surgery.It is a prospective cohort study which evaluated patients immediately before and 12 months following Roux-en-Y gastric bypass (RYGB).Mean score decreased from 1.142 to 0.066; surgery led to a resolution rate of advanced fibrosis of 55 %. Resolution was statistically associated with female gender, percentage of excess weight loss, postsurgical body mass index, postsurgical platelet count, and diabetes resolution.As previously reported by studies in which postsurgical biopsies were performed, RYGB leads to a great resolution rate of liver fibrosis. Since postsurgical biopsy is not widely available and has a significant risk, calculation of NAFLD fibrosis score is a simple tool to evaluate this evolution through a noninvasive approach.