α-tocopherol-doped irradiated UHMWPE for high fatigue resistance and low wear
α-tocopherol-doped irradiated UHMWPE for high fatigue resistance and low wear
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DOI：
10.1016/j.biomaterials.2003.12.048
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发表时间：
2004-11-01
期刊：
影响因子：
14
通讯作者：
Muratoglu, OK
中科院分区：
文献类型：
--
作者：
Oral, E;Wannomae, KK;Muratoglu, OK
超高分子量聚乙烯 (UHMWPE) 部件的磨损和疲劳会影响整个接头的使用寿命。交联减少了 UHMWPE 磨损，但与辐照后熔化相结合，也降低了其疲劳强度，因此限制了其在高应力应用中的使用。我们假设亲脂性抗氧化剂（α-生育酚，α-T）可以保护 UHMWPE 免受氧化，从而消除交联 UHMWPE 辐照后熔化的需要，并提高其疲劳强度。为了测试这些假设，使用了 65 kGy 和 100 kGy 辐照、α-T 掺杂以及随后伽马灭菌的 UHMWPE。 (I) 在 80°C 空气中加速老化 5 周后，与 100 kGy 辐照 UHMWPE (3.74+/-0.16) 相比，α-T 掺杂辐照 UHMWPE 显示出显着较低的氧化水平 (0.48+/-0.25 和 0.44+/-0.06)。 (II) α-T 掺杂辐照 UHMWPE 的磨损率（65 kGy 和 100 kGy 辐照 UHMWPE 分别为 1.9+/-0.5 和 0.9+/-0.1 mg/百万循环 (MC)）与 100 kGy 辐照/熔化 UHMWPE（1.1+/-0.7 mg/百万循环）相当。 (III) 100 kGy辐照的UHMWPE的裂纹萌生应力强度因子(DeltaK(i))在掺杂α-T后显着增加，从0.74 MPa m(1/2)增加到0.87 MPa m(1/2) (p
Longevity of total joints has been compromised by wear and fatigue of ultrahigh molecular weight polyethylene (UHMWPE) components. Crosslinking reduces UHMWPE wear, but combined with postirradiation melting, also reduces its fatigue strength, therefore limiting its use in high-stress applications. We hypothesized that a lipophilic antioxidant (alpha-tocopherol, alpha-T) can protect UHMWPE against oxidation eliminating the need for postirradiation melting of crosslinked UHMWPE and improve its fatigue strength. To test these hypotheses, 65- and 100-kGy irradiated, alpha-T-doped and subsequently gamma-sterilized UHMWPE were used. (I) alpha-T-doped irradiated UHMWPEs showed significantly lower oxidation levels (0.48+/-0.25 and 0.44+/-0.06) compared to 100-kGy irradiated UHMWPE (3.74+/-0.16) after 5 weeks of accelerated aging at 80degreesC in air. (II) Wear rate of alpha-T-doped irradiated UHMWPE (1.9+/-0.5, and 0.9+/-0.1 mg/million cycles (MC) for 65- and 100-kGy irradiated UHMWPE, respectively) were comparable to that of 100-kGy irradiated/melted UHMWPE (1.1+/-0.7 mg/million cycles). (III) The stress intensity factor at crack inception (DeltaK(i)) of 100-kGy irradiated UHMWPE increased significantly upon doping with alpha-T from 0.74 to 0.87 MPa m(1/2) (p