Neural mechanisms underlying food motivation in children and adolescents
Neural mechanisms underlying food motivation in children and adolescents
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DOI：
10.1016/j.neuroimage.2005.04.043
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发表时间：
2005-09-01
期刊：
影响因子：
5.7
通讯作者：
Savage, CR
中科院分区：
文献类型：
--
作者：
Holsen, LM;Zarcone, JR;Savage, CR
儿童肥胖的急剧增加需要更全面地了解儿童饥饿和饱食的神经机制。在这项研究中，正常体重的儿童和青少年在进食前后进行了功能性磁共振成像（fNIRl）扫描。参与者在餐前条件下对杏仁核，内侧额叶/眶额皮质和杏仁核中的视觉食物刺激表现出增加的激活;在餐后条件下没有感兴趣的区域响应。这些结果与先前在成人中的发现非常相似。此外，我们还发现了在餐前阶段杏仁核对食物刺激的习惯化的证据。这些发现提供了证据，表明与食物动机相关的正常神经活动模式开始童年。研究结果对肥胖儿童和成年人有启示，他们可能有异常的饥饿和饱足机制。(c)2005年爱思唯尔公司All rights reserved.
Dramatic increases in childhood obesity necessitate a more complete understanding of neural mechanisms of hunger and satiation in pediatric populations. In this study, normal weight children and adolescents underwent functional magnetic resonance imaging (fNIRl) scanning before and after eating a meal. Participants showed increased activation to visual food stimuli in the amygdala, medial frontal/orbitofrontal cortex, and insula in the pre-meal condition; no regions of interest responded in the post-meal condition. These results closely parallel previous findings in adults. In addition, we found evidence for habituation to food stimuli in the amygdala within the pre-meal session. These findings provide evidence that normal patterns of neural activity related to food motivation begin in childhood. Results have implications for obese children and adults, who may have abnormal hunger and satiation mechanisms. (c) 2005 Elsevier Inc. All rights reserved.