Human uterine endometrium and endometriotic tissue transplanted into nude mice. Morphologic effects of various steroid hormones.
Human uterine endometrium and endometriotic tissue transplanted into nude mice. Morphologic effects of various steroid hormones.
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发表时间：
1985-11
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通讯作者：
A. Bergqvist;S. Jeppsson;S. Kullander;O. Ljungberg
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作者：
A. Bergqvist;S. Jeppsson;S. Kullander;O. Ljungberg
在研究各种类固醇激素对人子宫内膜和子宫内膜异位组织的形态学影响时，将6名妇女的标本移植到24只裸鼠皮下。在每种情况下，将同时采集的标本移植到4只小鼠中，子宫内膜移植到一侧腹壁，子宫内膜组织移植到另一侧腹壁。术后第1天皮下注射聚磷酸雌二醇。间隔2周后，在每4只小鼠中，1只小鼠给予磷酸聚氧乙烯酯、1只醋酸甲羟孕酮、1只达那唑，1只不进一步注射。这种处理持续8周，之后处死小鼠并摘除移植物。移植物的组织学变化根据治疗方案而变化，但在两种类型的组织中非常相似。我们的研究结果表明，在自然条件下观察到的子宫内膜和子宫内膜异位组织之间的组织学差异可能，至少部分是由于环境因素的变化。
In a study of the morphologic effects of various steroid hormones on human uterine endometrium and endometriotic tissue, specimens from 6 women were transplanted subcutaneously into 24 nude mice. In each case, specimens collected simultaneously were transplanted to 4 mice, endometrium to one lateral abdominal wall and endometriotic tissue to the other. All mice were given polyestradiol phosphate subcutaneously the first day after operation. After a 2-week interval, of each 4 mice, 1 mouse was given polyestradiol phosphate, 1 medroxyprogesterone acetate, 1 danazol, and 1 no further injections. This treatment continued for 8 weeks, after which the mice were killed and the grafts extirpated. Histologic changes in the grafts varied according to the treatment schedule but were very similar in both types of tissue. Our findings suggest that histologic differences between endometrium and endometriotic tissue seen under natural conditions may, at least partly, be due to variations in environmental factors.