Neural correlates of self-reflection
Neural correlates of self-reflection
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DOI：
10.1093/brain/awf181
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发表时间：
2002-08-01
期刊：
影响因子：
14.5
通讯作者：
Prigatano, George P.
中科院分区：
文献类型：
--
作者：
Johnson, Sterling C.;Baxter, Leslie C.;Prigatano, George P.
反思自我意识的能力是自我意识的重要组成部分。在本文中，我们使用功能性 MRI 来研究一些自我反思背后的神经认知过程。使用血氧水平依赖性对比方法对 11 名健康志愿者进行了回波平面成像扫描。该任务包括需要做出是或否决定的口头陈述。在实验条件下，参与者对各种需要了解和反思自己的能力、特质和态度的陈述做出反应（例如“我忘记了重要的事情”、“我是一个好朋友”、“我脾气暴躁”）。在控制条件下，参与者对需要基本语义知识水平的陈述做出反应（例如“十秒比一分钟多”，“你需要水才能生存”）。后一个条件旨在控制听觉理解、注意力需求、决策、运动反应和任何常见的检索过程。个体分析显示所有参与者的前内侧前额叶和后扣带回激活一致。使用随机效应模型，该组的整体活动发生在前内侧前额叶皮层（t = 13.0，校正 P = 0.05；分别为 x、y、z、0、54、8）和后扣带回（t = 14.7，P = 0.02；分别为 x、y、z、-2、-62、32；967 体素范围）。这些数据与意识受损的病变研究一致，并表明内侧前额叶和后扣带皮层是支持自我反思思维的神经系统的一部分。
The capacity to reflect on one's sense of self is an important component of self-awareness. In this paper, we investigate some of the neurocognitive processes underlying reflection on the self using functional MRI. Eleven healthy volunteers were scanned with echoplanar imaging using the blood oxygen level-dependent contrast method. The task consisted of aurally delivered statements requiring a yes-no decision. In the,:experimental condition, participants responded to a variety of statements requiring knowledge of and reflection on their own abilities, traits and attitudes (e.g. 'I forget important things', 'I'm a good friend', 'I have a quick temper'). In the control condition, participants responded to statements requiring a basic level of semantic knowledge (e.g. 'Ten seconds is more than a minute', 'You need water to live'). The latter condition was intended to control for auditory comprehension, attentional demands, decision-making, the motoric response, and any common retrieval processes. Individual analyses revealed consistent anterior medial prefrontal and posterior cingulate activation for all participants. The overall activity for the group, using a random-effects model, occurred in anterior medial prefrontal cortex (t = 13.0, corrected P = 0.05; x, y, z, 0, 54, 8, respectively) and the posterior cingulate (t = 14.7, P = 0.02; x, y, z, -2, -62, 32, respectively; 967 voxel extent). These data are consistent with lesion studies of impaired awareness, and suggest that the medial prefrontal and posterior cingulate cortex are part of a neural system subserving self-reflective thought.