Synthesis of Polyethylene Glycol-Poly(glycerol carbonate) Block Copolymeric Micelles as Surfactant-Free Drug Delivery Systems.
Synthesis of Polyethylene Glycol-Poly(glycerol carbonate) Block Copolymeric Micelles as Surfactant-Free Drug Delivery Systems.
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DOI：
10.1021/acsmacrolett.3c00275
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发表时间：
2023-06
影响因子：
5.8
通讯作者：
D. Fitzgerald;Heng Zhang;C. Bordeianu;Y. Colson;M. Grinstaff
中科院分区：
文献类型：
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作者：
D. Fitzgerald;Heng Zhang;C. Bordeianu;Y. Colson;M. Grinstaff
本文报道了在钴盐催化剂下，通过开环聚合，将苄基缩水甘油醚、单甲氧基聚乙二醇和二氧化碳合成了单甲氧基聚乙二醇和聚碳酸甘油嵌段共聚物（mPEG-b-PGC）。所得到的嵌段共聚物具有较高的聚合物/环碳酸盐选择性（bbb99 %），如果使用两个氧环烷单体，则可以随机加入到聚合物进料中。由此产生的二嵌段mPEG-b-PGC聚合物有望成为一种无表面活性剂、持续化疗递送的纳米载体。mPEG-b-PGC将紫杉醇偶联到甘油聚合物骨架的垂链伯醇上，在溶液中容易形成直径175 nm的颗粒，含有4.6 wt %的紫杉醇（PTX），在42天内释放。mPEG-b-PGC聚合物本身没有细胞毒性，而负载ptx的纳米颗粒对肺癌、乳腺癌和卵巢癌细胞系具有细胞毒性。
We report the synthesis of block copolymers of monomethoxylated polyethylene glycol and poly(glycerol carbonate) (mPEG-b-PGC) via the ring-opening polymerization of benzyl glycidyl ether, monomethoxylated polyethylene glycol, and carbon dioxide using a cobalt salen catalyst. The resulting block copolymers display high polymer/cyclic carbonate selectivity (>99%) and, if two oxirane monomers are used, random incorporation into the polymer feed. The resulting diblock mPEG-b-PGC polymer shows promise as a nanocarrier for surfactant-free, sustained chemotherapeutic delivery. mPEG-b-PGC, with paclitaxel conjugated to the pendant primary alcohol of the glycerol polymer backbone, readily forms 175 nm diameter particles in solution and contains 4.6 wt % paclitaxel (PTX), which is released over 42 days. The mPEG-b-PGC polymer itself is noncytotoxic, whereas the PTX-loaded nanoparticles are cytotoxic to lung, breast, and ovarian cancer cell lines.