Meningitis and bacteremia due to Haemophilus influenzae: occurrence and mortality at Boston City Hospital in 12 selected years, 1935-1972.
Meningitis and bacteremia due to Haemophilus influenzae: occurrence and mortality at Boston City Hospital in 12 selected years, 1935-1972.
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流感嗜血杆菌引起的脑膜炎和菌血症：1935-1972 年 12 个选定年份在波士顿市医院的发生率和死亡率。
DOI：
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发表时间：
1974
影响因子：
6.4
通讯作者：
M. Finland
中科院分区：
文献类型：
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作者：
J. Mcgowan;J. Klein;L. Bratton;M. W. Barnes;M. Finland
在 1935 年至 1972 年间的 12 个选定年份中，从 79 名脑膜炎患者的脑脊液和其他 72 名未患脑膜炎的患者的血液中培养出流感嗜血杆菌。血清学鉴定的绝大多数菌株为 b 型。每个类别中还发现一例副流感嗜血杆菌。大多数（85%）脑膜炎患者年龄小于三岁；四个是成年人。在采用广谱抗生素后，与流感脑膜炎相关的死亡率下降到非常低的水平。 1957年以后，不伴有脑膜炎的流感嗜血菌菌血症病例有所增加。在婴儿和儿童中，此类病例最常与肺炎或气管支气管炎和蜂窝织炎有关，也与中耳炎、会厌炎和化脓性关节炎有关；除出生后前六个月的患者外，死亡率很低。在成人中，流感嗜血杆菌引起的菌血症主要集中在呼吸道或未确定，死亡率> 50%。
During 12 selected years between 1935 and 1972, Haemophilus influenzae was grown from cerebrospinal fluid of 79 patients with meningitis and from blood of 72 others without meningitis. The vast majority of strains identified serologically were type b. Haemophilus parainfluenzae was identified in one additional case in each category. Most (85%) of the patients with meningitis were less than three years old; four were adults. Mortality associated with influenzal meningitis declined to a very low rate after the introduction of broad-spectrum antibiotics. Cases of bacteremia due to H. influenzae without meningitis increased after 1957. In infants and children, such cases were associated most frequently with pneumonia or tracheobronchitis and cellulitis, and also with otitis, epiglottitis, and septic arthritis; the rate of mortality was low, except in patients in the first six months of life. In adults, the focus of bacteremia due to H. influenzae was either the respiratory tract or not determined, and mortality was > 50%.