Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme.
Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme.
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DOI：
10.23726/cij.2017.457
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发表时间：
2017-06
影响因子：
--
通讯作者：
Parker MA
中科院分区：
文献类型：
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作者：
Burnet NG;Scaife JE;Romanchikova M;Thomas SJ;Bates AM;Wong E;Noble DJ;Shelley LE;Bond SJ;Forman JR;Hoole AC;Barnett GC;Brochu FM;Simmons MP;Jena R;Harrison K;Yeap PL;Drew A;Silvester E;Elwood P;Pullen H;Sultana A;Seah SY;Wilson MZ;Russell SG;Benson RJ;Rimmer YL;Jefferies SJ;Taku N;Gurnell M;Powlson AS;Schönlieb CB;Cai X;Sutcliffe MP;Parker MA
VoxTox研究方案将物理科学的专门知识应用于放射治疗毒性问题，汇集了工程、数学、高能物理学（包括大型强子对撞机）、医学物理学和放射肿瘤学的专门知识。在我们的初始队列中，109例接受前列腺癌根治性放疗的男性，每日图像引导计算机断层扫描（CT）扫描已用于计算直肠的输送剂量，与计划剂量不同，使用自动化方法。已经收集了临床毒性数据，使我们能够解决递送剂量比计划剂量提供更好的毒性预测的假设。
The VoxTox research programme has applied expertise from the physical sciences to the problem of radiotherapy toxicity, bringing together expertise from engineering, mathematics, high energy physics (including the Large Hadron Collider), medical physics and radiation oncology. In our initial cohort of 109 men treated with curative radiotherapy for prostate cancer, daily image guidance computed tomography (CT) scans have been used to calculate delivered dose to the rectum, as distinct from planned dose, using an automated approach. Clinical toxicity data have been collected, allowing us to address the hypothesis that delivered dose provides a better predictor of toxicity than planned dose.