Cutaneous findings in Fanconi anemia.
Cutaneous findings in Fanconi anemia.
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DOI：
10.1016/j.jaad.2020.08.047
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发表时间：
2021-11
影响因子：
13.8
通讯作者：
Boull C
中科院分区：
文献类型：
--
作者：
Ruggiero JL;Dodds M;Freese R;Polcari IC;Maguiness S;Hook KP;Boull C
Fanconi anemia (FA) is a genetic disorder that results in bone marrow failure, physical abnormalities, and solid organ malignancies. The diagnosis of FA is often delayed as the early disease characteristics have not been well established. To outline the spectrum of cutaneous findings seen in patients with FA. A cross-sectional study, where patients with FA received a full-body skin exam. Patient characteristics were summarized with mean (sd) for continuous and count (%) for categorical variables. Poisson regression and logistic regression models were used to examine the relationships between pigmentary changes and patient characteristics. Nearly all of the patients (96.8%) had at least one cutaneous pigmentary alteration, most arising prior to the teenage years. The most common finding was café-au-lait macules (CALM). Other findings included hypopigmented macules, skin-fold freckle-like macules, extensive sun-exposed freckling, and both hypo- and hyperpigmented pigment macules. Patients received a single assessment, so the number of pigmentary changes could not be assessed over time. Characteristic morphology of FA includes faint and ill-defined CALM, hypopigmented skin-fold freckle-like macules and the concurrence of hypo- and hyperpigmented macules. The recognition of these findings could aid clinicians in making earlier diagnoses.
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影响因子：
1.7
作者：
Xiao-Kai, Fang;Yue-Xi, He;Qing, Sun
通讯作者：
Qing, Sun
DOI：
10.1016/j.hoc.2009.01.008
发表时间：
2009-04
期刊：
Hematology/oncology clinics of North America
影响因子：
--
作者：
Green AM;Kupfer GM
通讯作者：
Kupfer GM
影响因子：
--
作者：
Schnur, RE;Heymann, WR
通讯作者：
Heymann, WR
影响因子：
3
作者：
De Schepper, S;Boucneau, J;Lambert, J
通讯作者：
Lambert, J
影响因子：
4
作者：
GLANZ, A;FRASER, FC
通讯作者：
FRASER, FC