Neural crest and cardiovascular development: A 20-year perspective.
Neural crest and cardiovascular development: A 20-year perspective.
复制标题
DOI：
10.1002/bdrc.10002
复制
发表时间：
2003-02-01
影响因子：
2.1
通讯作者：
Kirby, Margaret L.
中科院分区：
文献类型：
--
作者：
Hutson, Mary Redmond;Kirby, Margaret L.
背景资料：20年前的这一年，第一篇文章描述了正常心血管发育所必需的神经嵴细胞区域。鸡的这一区域的消融导致持续性动脉干，大血管的错位，流出道排列不良，以及咽腺发育不全或发育不全。研究方法：我们开始与历史的角度，然后审查已取得的进展，在随后的20年中，在确定的直接和间接的贡献的神经嵴细胞，现在被称为心脏神经嵴细胞，在心血管和咽弓的发展。许多分子途径，现在已知的影响规格，迁移，图案化和最终的心脏神经嵴细胞的目标也进行了审查。结果如下：虽然通过使用许多遗传操作来了解心脏神经嵴细胞在心血管发育中的作用已经获得了很多知识，但大多数模型都无法解释在综合征和非综合征人类先天性心脏缺陷中观察到的表型，例如DiGeorge综合征。结论：我们建议，心脏神经嵴存在的一部分，一个更大的cardiocraniofacial形态发生领域，并描述了几个人类综合征，导致这一领域的异常发展。
Background: Twenty years ago this year was the first publication describing a region of neural crest cells necessary for normal cardiovascular development. Ablation of this region in chick resulted in persistent truncus arteriosus, mispatterning of the great vessels, outflow malalignments, and hypoplasia or aplasia of the pharyngeal glands. Methods: We begin with a historical perspective and then review the progress that has been made in the ensuing 20 years in determining the direct and indirect contributions of the neural crest cells, now termed cardiac neural crest cells, in cardiovascular and pharyngeal arch development. Many of the molecular pathways that are now known to influence the specification, migration, patterning and final targeting of the cardiac neural crest cells are also reviewed. Results: Although much knowledge has been gained by using many genetic manipulations to understand the cardiac neural crest cells' role in cardiovascular development, most models fail to explain the phenotypes seen in syndromic and non-syndromic human congenital heart defects, such as the DiGeorge syndrome. Conclusions: We propose that the cardiac neural crest exists as part of a larger cardiocraniofacial morphogenetic field and describe several human syndromes that result from abnormal development of this field.