Meibomian Gland Dysfunction: Recent Progress Worldwide and in Japan
Meibomian Gland Dysfunction: Recent Progress Worldwide and in Japan
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DOI：
10.1167/iovs.17-23553
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发表时间：
2018-11-01
影响因子：
4.4
通讯作者：
Amano, Shiro
中科院分区：
文献类型：
--
作者：
Amano, Shiro
本文从全球睑板腺功能障碍的学术研究和临床研究的角度，探讨日本睑板腺功能障碍研究的重要性。许多日本医生和研究人员在MGD研究的各个领域，包括病理生理学，流行病学，诊断和治疗，为最近的全球进展做出了贡献。在日本，病理生理学领域的最新研究为脂质成分和活性氧在MGD的发展和恶化中起关键作用的假设提供了直接证据。在诊断领域，裂隙灯检查、体内共聚焦显微镜和睑板造影术已广泛用于日本的研究。在这些研究结果的基础上，日本的MGD工作组提出了阻塞性MGD的新诊断标准。根据这些标准，当存在眼部症状、解剖异常和睑板腺阻塞时，认为存在阻塞性MGD。在治疗领域，日本新开发的设备和药物已被证明可以提高眼睑卫生和温压的功效。此外，地夸磷索和维生素D3已被证明对MGD有效。总之，MGD的诊断和治疗的标准化是必要的，使所有的MGD患者接受适当的治疗，和具体的诊断标准与截止值的每个参数是必要的，以标准化的MGD的诊断。
In this review, the importance of Japanese research on meibomian gland dysfunction (MGD) is discussed from the perspective of global academic and clinical research on this topic. Many Japanese physicians and researchers have contributed to recent worldwide progress in various fields of MGD research, including pathophysiology, epidemiology, diagnosis, and therapy. In Japan, recent studies in the field of pathophysiology have provided direct evidence for the hypothesis that lipid composition and reactive oxygen species play a crucial role in the development and worsening of MGD. In the field of diagnosis, slit-lamp examination, in vivo confocal microscopy, and meibography have been widely used in studies from Japan. On the basis of the results of these studies, the MGD working group in Japan has proposed new diagnostic criteria for obstructive MGD. According to these criteria, obstructive MGD is considered present when ocular symptoms, anatomic abnormalities, and meibomian gland obstruction are present. In the field of therapy, devices and drugs newly developed in Japan have been shown to enhance the efficacy of lid hygiene and warm compression. Moreover, diquafosol and vitamin D3 have been shown to be effective for MGD. In conclusion, standardization of the diagnosis and treatment of MGD is necessary to enable all patients with MGD to receive appropriate treatment, and specific diagnostic criteria with cutoff values for each parameter are necessary to standardize the diagnosis of MGD.