ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons
ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons
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DOI：
10.1016/s0092-8674(00)80859-4
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发表时间：
2000-05-26
期刊：
影响因子：
64.5
通讯作者：
Jessell, TM
中科院分区：
文献类型：
--
作者：
Arber, S;Ladle, DR;Jessell, TM
感觉神经元和运动神经元之间的连接在运动行为的控制中起着至关重要的作用。在发育过程中，本体感觉神经元的轴突投射到脊髓中，并与MNs形成直接和间接的连接。两个ETS转录因子ER81和PEAS在发育中的本体感觉神经元和MNs中表达，这提高了这些基因参与感觉-运动连接形成的可能性。Er81突变小鼠表现出严重的运动失调，但MNs的特异性和肌纺锤体的诱导正常发生。Er81突变体的运动缺陷是由于本体感觉传入事件组无法在脊髓腹侧形成一个离散的终止区。其结果是本体感觉传入事件和神经网络之间的直接连接的形成急剧减少。因此，ER81控制着在发育中的脊髓中建立功能性感觉-运动回路的最后一步。
The connections formed between sensory and motor neurons (MNs) play a critical role in the control of motor behavior. During development, the axons of proprioceptive sensory neurons project into the spinal cord and form both direct and indirect connections with MNs. Two ETS transcription factors, ER81 and PEAS, are expressed by developing proprioceptive neurons and MNs, raising the possibility that these genes are involved in the formation of sensory-motor connections. Er81 mutant mice exhibit a severe motor discoordination, yet the specification of MNs and induction of muscle spindles occurs normally. The motor defect in Er81 mutants results from a failure of group la proprioceptive afferents to form a discrete termination zone in the ventral spinal cord. As a consequence there is a dramatic reduction in the formation of direct connections between proprioceptive afferents and MNs. ER81 therefore controls a late step in the establishment of functional sensory-motor circuitry in the developing spinal cord.