Herpesvirus-like DNA sequences in non-AIDS Kaposi's sarcoma.
Herpesvirus-like DNA sequences in non-AIDS Kaposi's sarcoma.
复制标题
非艾滋病卡波西肉瘤中的疱疹病毒样 DNA 序列。
DOI：
--
复制
发表时间：
1995
影响因子：
6.4
通讯作者：
P. Monini
中科院分区：
文献类型：
--
作者：
L. De Lellis;M. Fabris;E. Cassai;A. Corallini;G. Giraldo;C. Féo;P. Monini
卡波西肉瘤（KS）的发病机制可能与性接触传播的传染因子有关。最近，在艾滋病相关的KS中发现了与γ疱疹病毒科同源的DNA序列，但在非艾滋病相关的KS中尚无相关信息。分析了5例经典、12例地方性和17例艾滋病相关的KS皮肤病变标本，结果均为这些新的DNA序列阳性。24例正常皮肤呈阴性。这些新的序列也在人类免疫缺陷病毒阳性艾滋病患者或淋巴结病综合征患者的淋巴结中发现，但在正常受试者的外周血单个核细胞中未发现。因此，这些数据支持一种新型γ疱疹病毒可能与KS发病机制特异性相关的观点。
The pathogenesis of Kaposi's sarcoma (KS) is suggested to be related to an infectious agent transmitted by sexual contact. Recently, DNA sequences homologous to gamma herpesviridae have been identified in AIDS-associated KS, but no information is available concerning non-AIDS-associated KS. Five classic, 12 endemic, and 17 AIDS-associated KS skin lesion specimens were analyzed and all were positive for these novel DNA sequences. Twenty-four specimens from normal skin were negative. These novel sequences were also found in lymph nodes from human immunodeficiency virus-positive patients with AIDS or lymphadenopathy syndrome but not in peripheral blood mononuclear cells from normal subjects. Therefore, the data support the view that a novel gamma herpesvirus might be specifically associated with KS etiopathogenesis.