Is there a mitochondrial signaling complex facilitating cholesterol import?
Is there a mitochondrial signaling complex facilitating cholesterol import?
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DOI：
10.1016/j.mce.2006.12.004
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发表时间：
2007-02-01
影响因子：
4.1
通讯作者：
Culty, Martine
中科院分区：
文献类型：
--
作者：
Papadopoulos, Vassilios;Liu, Jun;Culty, Martine
胆固醇转运进入线粒体是类固醇生物合成中的速率决定和代谢敏感步骤。在过去的几年中，两种蛋白质被证明是至关重要的这一过程：线粒体转运蛋白，以前被称为外周型苯二氮卓受体，和类固醇生成急性调节蛋白。在这份手稿中，我们审查的证据表明，这两种蛋白质功能相互作用，以促进胆固醇运输，并可能是一个更大的多聚体线粒体蛋白质复合物的一部分组装，以促进胆固醇诱导的胆固醇转移到线粒体。该复合物可能包括蛋白质，如线粒体电压依赖性阴离子通道、转运蛋白相关蛋白PAP 7，其也作为A激酶锚蛋白发挥作用，其结合cAMP依赖性蛋白激酶的调节亚基I α并将其带入复合物中。(c)2007年由Elsevier爱尔兰有限公司出版。
Cholesterol transport into mitochondria is the rate-determining and hormone-sensitive step in steroid biosynthesis. During the last few years two proteins were shown to be critical for this process: the mitochondrial translocator protein, previously known as peripheral-type benzodiazepine receptor, and the steroidogenic acute regulatory protein. In this manuscript we review evidence suggesting that these two proteins functionally interact to facilitate cholesterol transport and may be part of a larger multimeric mitochondrial complex of proteins assembled to facilitate the hormone-induced cholesterol transfer into mitochondria. This complex might include proteins such as the mitochondrial voltage-dependent anion channel, the translocator protein-associated protein PAP7 which also functions as an A kinase anchor protein that binds and brings into the complex the regulatory subunit I alpha of the cAMP-dependent protein kinase. (c) 2007 Published by Elsevier Ireland Ltd.