Disk degeneration and low back pain: are they fat-related conditions?
Disk degeneration and low back pain: are they fat-related conditions?
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DOI：
10.1055/s-0033-1350054
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发表时间：
2013-06
影响因子：
2.4
通讯作者：
Lotz J
中科院分区：
文献类型：
--
作者：
Samartzis D;Karppinen J;Cheung JP;Lotz J
下背痛（LBP）是世界上最令人衰弱的疾病。椎间盘退变被认为是LBP的一个重要决定因素。超重和肥胖是影响全世界每一个人口的公共卫生问题，其流行率继续上升。研究表明，超重/肥胖与椎间盘退变以及LBP之间存在密切联系。这篇广泛的叙述性综述文章讨论了在超重/肥胖背景下可能导致椎间盘退变和/或LBP的各种机制。特别是，我们的目标是提高人们对脂肪细胞的作用及其通过改变代谢或释放脂肪因子以及可能导致椎间盘退变和LBP发展的其他途径的参与的认识。了解脂肪在这一过程中的作用可能有助于开发新的生物疗法和技术，以阻止进展或再生椎间盘。此外，随着遗传学的进步和对遗传流行病学的认识，更个性化的脊柱护理方法可能必须考虑脂肪在任何预防，治疗和/或预后方式中对椎间盘和LBP的作用。
Low back pain (LBP) is the world's most debilitating condition. Disk degeneration has been regarded as a strong determinant associated with LBP. Overweight and obesity are public health concerns that affect every population worldwide and whose prevalence continues to rise. Studies have indicated strong associations between overweight/obesity and disk degeneration as well as with LBP. This broad narrative review article addresses the various mechanisms that may be involved leading to disk degeneration and/or LBP in the setting of overweight/obesity. In particular, our goal is to raise awareness of the role of fat cells and their involvement via altered metabolism or the release of adipokines as well as other pathways that may lead to the development of disk degeneration and LBP. Understanding the role of fat in this process may aid in the development of novel biological therapies and technologies to halt the progression or regenerate the disk. Moreover, with genetic advancements and the appreciation of genetic epidemiology, a more personalized approach to spine care may have to consider the role of fat in any preventative, therapeutic, and/or prognosis modalities toward the disk and LBP.